Alexander R. Abbas

TL;DR: This work shows that interleukin-22 (IL-22) has a crucial role in the early phase of host defense against C. rodentium and identifies a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens.

TL;DR: Asthma can be divided into at least two distinct molecular phenotypes defined by degree of Th2 inflammation, and Th2 cytokines are likely to be a relevant therapeutic target in only a subset of patients with asthma.

TL;DR: The expansion and activation of monocytes, NK cells, and T helper cells in SLE at least partly underlie this disease's prominent interferon signature, and patterns of leukocyte dynamics uncovered here correlate with disease severity and treatment, suggest potential new treatments, and extend the understanding of lupus pathology as a complex autoimmune disease involving many arms of the immune system.

TL;DR: A compendium of microarray expression data for virtually all human genes from six key immune cell types and their activated and differentiated states, indicating that immune specificity is important at many points in the signaling pathways of the immune response.

TL;DR: It is demonstrated that asthma can be divided into three immunological clusters: TH2-high, TH17- high, and TH2/17- low, and the data suggest that combination therapies targeting both pathways may better treat asthmatic individuals.