J
John V. Fahy
Researcher at University of California, San Francisco
Publications - 274
Citations - 31784
John V. Fahy is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Asthma & Sputum. The author has an hindex of 81, co-authored 235 publications receiving 27724 citations. Previous affiliations of John V. Fahy include University of California & St. Vincent's Health System.
Papers
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Journal ArticleDOI
T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma
Prescott G. Woodruff,Barmak Modrek,David F. Choy,Guiquan Jia,Alexander R. Abbas,Almut Ellwanger,Joseph R. Arron,Laura L. Koth,John V. Fahy +8 more
TL;DR: Asthma can be divided into at least two distinct molecular phenotypes defined by degree of Th2 inflammation, and Th2 cytokines are likely to be a relevant therapeutic target in only a subset of patients with asthma.
Journal ArticleDOI
Airway mucus function and dysfunction.
John V. Fahy,Burton F. Dickey +1 more
TL;DR: Pulmonary defense against environmental injury depends on airway mucus, which traps inhaled toxins that are then cleared from the lungs by ciliary beating and cough.
Journal ArticleDOI
Type 2 inflammation in asthma — present in most, absent in many
TL;DR: How dichotomizing asthma according to levels of type 2 inflammation — into 'T helper 2 (TH2)-high' and 'TH2-low' subtypes (endotypes) — has shaped the thinking about the pathobiology of asthma and has generated new interest in understanding the mechanisms of disease that are independent of type 1 inflammation is considered.
Journal ArticleDOI
Proceedings of the ATS Workshop on Refractory Asthma Current Understanding, Recommendations, and Unanswered Questions
Sally E. Wenzel,John V. Fahy,Charles G. Irvin,Stephen P. Peters,Sheldon L. Spector,Stanley J. Szefler,Thomas B. Casale,Michelle M. Cloutier,Jack A. Elias,Mark C. Liu,Virginia Taggert +10 more
TL;DR: The proceedings of an American Thoracic Society (ATS)-sponsored workshop are hoped to serve as an aid to begin to define, understand, and manage these refractory patients.
Journal ArticleDOI
Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids
Prescott G. Woodruff,Homer A. Boushey,Gregory Dolganov,Christopher S. Barker,Yee Hwa Yang,Samantha Donnelly,Almut Ellwanger,Sukhvinder Sidhu,Trang Dao-Pick,Carlos R. Pantoja,David J. Erle,Keith R. Yamamoto,John V. Fahy +12 more
TL;DR: The findings show that airway epithelial cells in asthma have a distinct activation profile and identify direct and cell-autonomous effects of corticosteroid treatment on airway endothelial cells that relate to treatment responses and can now be the focus of specific mechanistic studies.