D
Daryl T. Baldwin
Researcher at Genentech
Publications - 20
Citations - 5324
Daryl T. Baldwin is an academic researcher from Genentech. The author has contributed to research in topics: Receptor & Vascular endothelial growth inhibitor. The author has an hindex of 12, co-authored 20 publications receiving 5132 citations.
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Journal ArticleDOI
Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors
James P. Sheridan,Scot A. Marsters,Robert M. Pitti,Austin L. Gurney,Maya Skubatch,Daryl T. Baldwin,Lakshmi Ramakrishnan,Christa L. Gray,Kevin P. Baker,William I. Wood,Audrey Goddard,Paul J. Godowski,Avi Ashkenazi +12 more
TL;DR: A cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli in tumor cells.
Journal ArticleDOI
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
Robert M. Pitti,Scot A. Marsters,David A. Lawrence,Margaret Ann Roy,Frank C. Kischkel,Patrick Dowd,Arthur J Huang,Christopher J. Donahue,Steven Sherwood,Daryl T. Baldwin,Paul J. Godowski,William I. Wood,Austin L. Gurney,Kenneth J. Hillan,Robert L. Cohen,Audrey Goddard,David Botstein,Avi Ashkenazi +17 more
TL;DR: Certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL, which was amplified in about half of 35 primary lung and colon tumours studied and DcR3 messenger RNA was expressed in malignant tissue.
Journal ArticleDOI
A novel receptor for Apo2L/TRAIL contains a truncated death domain
Scot A. Marsters,James P. Sheridan,R.M. Pitti,Arthur J Huang,M. Skubatch,Daryl T. Baldwin,Yuan Jean,A. Gurney,A.D. Goddard,Paulj. Godowski,Avi Ashkenazi +10 more
TL;DR: Results suggest that DcR2 functions as an inhibitory Apo2L receptor, which contains a cytoplasmic region with a truncated death domain and was particularly abundant in fetal liver and adult testis.
Journal ArticleDOI
The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment
Hilary Clark,Austin L. Gurney,Evangeline Abaya,Kevin P. Baker,Daryl T. Baldwin,Jennifer Brush,Jian Chen,Bernard Chow,Clarissa Chui,Craig Crowley,Bridget Currell,Bethanne Deuel,Patrick Dowd,Dan L. Eaton,Jessica Foster,Christopher Grimaldi,Qimin Gu,Philip E. Hass,Sherry Heldens,Arthur J Huang,Hok Seon Kim,Laura Klimowski,Yisheng Jin,Stephanie Johnson,James Lee,Lhney Lewis,Dongzhou Liao,Melanie R. Mark,Edward P. Robbie,Celina Sanchez,Jill Schoenfeld,Somasekar Seshagiri,Laura Simmons,Jennifer Singh,Victoria Smith,Jeremy Stinson,Alicia Vagts,Richard Vandlen,Colin K. Watanabe,David Wieand,Kathryn Woods,Ming-Hong Xie,Daniel G. Yansura,Sothy Yi,Guoying Yu,Jean Yuan,Min Zhang,Zemin Zhang,Audrey Goddard,William I. Wood,Paul J. Godowski +50 more
TL;DR: The SPDI collection should facilitate efforts to better understand intercellular communication, may lead to new understandings of human diseases, and provides potential opportunities for the development of therapeutics.
Journal ArticleDOI
IL-17E, a Novel Proinflammatory Ligand for the IL-17 Receptor Homolog IL-17Rh1
James Lee,Wei-Hsien Ho,Miko Maruoka,Racquel Corpuz,Daryl T. Baldwin,Jessica Foster,Audrey Goddard,Daniel G. Yansura,Richard Vandlen,William I. Wood,Austin L. Gurney +10 more
TL;DR: In this article, the identification of interleukin (IL)-17E, a member of the IL-17 family of cytokines, was reported, which induces activation of NF-κB and stimulates production of the proinflammatory chemokine IL-8.