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Alexander V. Statsyuk
Researcher at University of Houston
Publications - 31
Citations - 671
Alexander V. Statsyuk is an academic researcher from University of Houston. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 13, co-authored 30 publications receiving 543 citations. Previous affiliations of Alexander V. Statsyuk include Northwestern University & Northwest University (United States).
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A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases.
TL;DR: A novel fragment-based drug discovery approach is reported which irreversibly tethers drug-like fragments to catalytic cysteines and displays specificity.
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A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism.
Stefan G. Kathman,Ingrid Span,Aaron T. Smith,Ziyang Xu,Jennifer Zhan,Amy C. Rosenzweig,Alexander V. Statsyuk +6 more
TL;DR: The discovery that the HECT E3 Nedd4-1 is a processive enzyme and that disruption of its processivity by biochemical mutations or small molecules switches Nedd 4-1 from a processives to a distributive mechanism of polyubiquitin chain synthesis is reported.
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Covalent Tethering of Fragments For Covalent Probe Discovery
TL;DR: How covalent tethering was developed, its current state, and its future are highlighted, as well as the risk of selecting the most reactive fragment rather than the best binder if the covalents fragments are screened in mixtures.
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Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways.
Heeseon An,Alexander V. Statsyuk +1 more
TL;DR: The development of a mechanism-based small-molecule probe, ABP1, is described that can be used to discover and to detect active UBL proteins, and to monitor the intracellular activity of E1 enzymes inside intact cells.
Journal ArticleDOI
An inhibitor of ubiquitin conjugation and aggresome formation
Heeseon An,Alexander V. Statsyuk +1 more
TL;DR: An inhibitor of ubiquitin activating E1 enzyme inhibits Ubiquitin conjugation and aggresome formation.