A
Alexandr Kristian
Researcher at Oslo University Hospital
Publications - 34
Citations - 837
Alexandr Kristian is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 15, co-authored 27 publications receiving 724 citations. Previous affiliations of Alexandr Kristian include University of Oslo & The Breast Cancer Research Foundation.
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Journal ArticleDOI
B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation
Hao Liu,Christina Tekle,Yih Wen Chen,Alexandr Kristian,Yuhua Zhao,Ming Zhou,Zixing Liu,Yan Ding,Bin Wang,Gunhild Mari Mælandsmo,Jahn M. Nesland,Øystein Fodstad,Ming Tan +12 more
TL;DR: The data show that in breast cancer cells, B7-H3 induces paclitaxel resistance, at least partially by interfering with Jak2/Stat3 pathway, and encourage the design and testing of approaches targeting this protein and its partners.
Journal ArticleDOI
Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model
H Almåsbak,E. Walseng,Alexandr Kristian,M R Myhre,E M Suso,Ludvig A. Munthe,Jan Terje Andersen,Mengyu Wang,Gunnar Kvalheim,Gustav Gaudernack,Jon Amund Kyte +10 more
TL;DR: The results show that transiently redirected T cells control leukemia in mice and support the rationale for developing an mRNA-CAR platform.
Journal ArticleDOI
Aldehyde Dehydrogenase (ALDH) Activity Does Not Select for Cells with Enhanced Aggressive Properties in Malignant Melanoma
Lina Prasmickaite,Birgit Engesæter,Nirma Skrbo,Tina Hellenes,Alexandr Kristian,Nina K. Oliver,Zhenhe Suo,Gunhild Mari Mælandsmo,Gunhild Mari Mælandsmo +8 more
TL;DR: It is suggested that ALDH does not distinguish tumour-initiating and/or therapy-resistant cells, implying that the ALDH phenotype is not associated with more-aggressive subpopulations in malignant melanoma, and arguing against ALDH as a “universal” marker.
Journal ArticleDOI
Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer
Yang Jin,Su Qu,Martina Tesikova,Ling Wang,Alexandr Kristian,Gunhild Mari Mælandsmo,Haiying Kong,Tianzhou Zhang,Carmen Jerónimo,Manuel R. Teixeira,Erkan Yuca,Ibrahim Tekedereli,Kivanc Gorgulu,Neslihan Alpay,Anil K. Sood,Gabriel Lopez-Berestein,Håvard E. Danielsen,Bulent Ozpolat,Fahri Saatcioglu,Fahri Saatcioglu +19 more
TL;DR: It is shown that proteins encoded by two androgen-regulated genes, kallikrein related peptidase 4 (KLK4) and promyelocytic leukemia zinc finger (PLZF), integrate optimal functioning of AR and mTOR signaling in PCa cells, which may be a viable target for therapy.
Journal ArticleDOI
STAMP2 increases oxidative stress and is critical for prostate cancer
Yang Jin,Ling Wang,Su Qu,Xia Sheng,Xia Sheng,Alexandr Kristian,Gunhild Mari Mælandsmo,Nora Pällmann,Erkan Yuca,Ibrahim Tekedereli,Kivanc Gorgulu,Neslihan Alpay,Anil K. Sood,Gabriel Lopez-Berestein,Ladan Fazli,Paul S. Rennie,Björn Risberg,Håkon Wæhre,Håvard E. Danielsen,Bulent Ozpolat,Fahri Saatcioglu,Fahri Saatcioglu +21 more
TL;DR: It is shown that STAMP2 protein expression is increased in human PCa compared with benign prostate that is also correlated with tumor grade and treatment response, and therapeutic silencing by systemically administered nanoliposomal siRNA profoundly inhibited tumor growth in two established preclinical PCa models in mice.