F
Fahri Saatcioglu
Researcher at University of Oslo
Publications - 93
Citations - 5189
Fahri Saatcioglu is an academic researcher from University of Oslo. The author has contributed to research in topics: Prostate cancer & LNCaP. The author has an hindex of 42, co-authored 90 publications receiving 4672 citations. Previous affiliations of Fahri Saatcioglu include Harvard University & Oslo University Hospital.
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Journal ArticleDOI
Cross-talk between Transforming Growth Factor-β and Estrogen Receptor Signaling through Smad3
TL;DR: Evidence is provided that this two-way cross-talk between the estrogen and TGF-β signaling pathways was the result of direct physical interactions between Smad3 and ER, which has implications for a variety of disease states, such as the pathophysiology of kidney function, atherosclerosis, and breast cancer.
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CREB binding protein is a coactivator for the androgen receptor and mediates cross-talk with AP-1.
TL;DR: CBP significantly increased the ability of endogenous AR in LNCaP cells to activate transcription from an AR-dependent reporter construct and that the transcriptional interference between AR and AP-1 is the result of competition for limiting amounts of CBP in the cell.
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Antiestrogenic Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Are Mediated by Direct Transcriptional Interference with the Liganded Estrogen Receptor CROSS-TALK BETWEEN ARYL HYDROCARBON- AND ESTROGEN-MEDIATED SIGNALING
Indira Kharat,Fahri Saatcioglu +1 more
TL;DR: In this article, the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated at the molecular level.
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Androgenic Induction of Prostate-Specific Antigen Gene Is Repressed by Protein-Protein Interaction Between the Androgen Receptor and AP-1/c-Jun in the Human Prostate Cancer Cell Line LNCaP
Naohide Sato,Marianne D. Sadar,Nicholas Bruchovsky,Fahri Saatcioglu,Paul S. Rennie,Sayuri Sato,Paul H. Lange,Martin E. Gleave +7 more
TL;DR: Findings together with results obtained from co-immunoprecipitation experiments strongly suggest that mutual repression of DNA binding activity is due to direct interaction between the two proteins and that the degree of repression may be determined by the ratio of AR to c-Jun.
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Coordinated Regulation of Nutrient and Inflammatory Responses by STAMP2 Is Essential for Metabolic Homeostasis
Kathryn E. Wellen,Raquel Fucho,Margaret F. Gregor,Masato Furuhashi,Carlos Morgan,Torstein Lindstad,Eric Vaillancourt,Cem Z. Görgün,Fahri Saatcioglu,Gökhan S. Hotamisligil +9 more
TL;DR: It is concluded that STAMP2 participates in integrating inflammatory and metabolic responses and thus plays a key role in systemic metabolic homeostasis.