Alexandra Bernshausen

TL;DR: These studies document a developmental paradigm for cardiogenesis, where muscle and endothelial lineage diversification arises from a single cell-level decision of a multipotent isl1(+) cardiovascular progenitor cell (MICP).

TL;DR: It is shown, using genetic fate‐mapping, that Isl1+ multipotent cardiovascular progenitors can be generated from mouse iPS cells and spontaneously differentiate in all 3 cardiovascular lineages in vivo without teratoma.

TL;DR: It is reported that E1A-deleted or mutant adenovirus vectors, such as Ad312 and Ad520, replicate efficiently in multidrug-resistant (MDR) cancer cells and induce an adenvirus cytopathic effect resulting in host cell lysis, which forms the basis for the development of novel oncolytic adenavirus vectors for the treatment of MDR malignant diseases in the clinical setting.

TL;DR: It is reported that an oncolytic adenovirus, named Xvir03, expressing the viral proteins E1B55k and E4orf6, leads to nuclear translocation of YB-1 and in consequence to viral replication and cell lysis in vitro and in vivo and provides the basis for formulating a model for a novel combined therapy regimen named Mutually Synergistic Therapy.