Multipotent Embryonic Isl1+ Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification
Alessandra Moretti,Leslie Caron,Atsushi Nakano,Jason T. Lam,Jason T. Lam,Alexandra Bernshausen,Yinhong Chen,Yibing Qyang,Lei Bu,Mika Sasaki,Silvia Martin-Puig,Yunfu Sun,Sylvia M. Evans,Karl-Ludwig Laugwitz,Karl-Ludwig Laugwitz,Kenneth R. Chien +15 more
TLDR
These studies document a developmental paradigm for cardiogenesis, where muscle and endothelial lineage diversification arises from a single cell-level decision of a multipotent isl1(+) cardiovascular progenitor cell (MICP).About:
This article is published in Cell.The article was published on 2006-12-15 and is currently open access. It has received 1050 citations till now. The article focuses on the topics: Endothelial stem cell & Progenitor cell.read more
Citations
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Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development.
Charles E. Murry,Gordon Keller +1 more
TL;DR: The potential to generate virtually any differentiated cell type from embryonic stem cells (ESCs) offers the possibility to establish new models of mammalian development and to create new sources of cells for regenerative medicine, but it is essential to be able to control ESC differentiation and to direct the development of these cells along specific pathways.
Journal ArticleDOI
Human cardiovascular progenitor cells develop from a KDR + embryonic-stem-cell-derived population
Lei Yang,Mark H. Soonpaa,Eric Adler,Torsten K. Roepke,Steven J. Kattman,Marion Kennedy,Els Henckaerts,Kristina Bonham,Geoffrey W. Abbott,R. Michael Linden,R. Michael Linden,Loren J. Field,Gordon Keller,Gordon Keller +13 more
TL;DR: Analysis of the development of the cardiovascular lineages in human embryonic stem cell differentiation cultures identifies a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development.
Journal ArticleDOI
miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
Kimberly R. Cordes,Neil T. Sheehy,Mark P. White,Emily C. Berry,Sarah U. Morton,Alecia N. Muth,Ting-Hein Lee,Joseph M. Miano,Kathryn N. Ivey,Deepak Srivastava +9 more
TL;DR: It is demonstrated that miR-145 can direct the smooth muscle fate and that mi R-145 and miR -143 function to regulate the quiescent versus proliferative phenotype of smooth muscle cells.
Journal ArticleDOI
Stem-cell therapy for cardiac disease
TL;DR: In conclusion, resident cardiac stem cells have been shown to differentiate into multiple cell types present in the heart, including cardiac muscle cells, indicating that the heart is not terminally differentiated.
Journal ArticleDOI
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
Alessandra Moretti,Milena Bellin,Andrea Welling,Christian Jung,Jason T. Lam,Lorenz Bott-Flügel,Tatjana Dorn,Alexander Goedel,Christian Höhnke,Franz Hofmann,Melchior Seyfarth,Daniel Sinnecker,Albert Schömig,Karl-Ludwig Laugwitz +13 more
TL;DR: It was shown that myocytes derived from patients with long-QT syndrome type 1 had an increased susceptibility to catecholamine-induced tachyarrhythmia and that beta-blockade attenuated this phenotype.
References
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Journal ArticleDOI
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice.
Fouad Shalaby,Janet Rossant,Janet Rossant,Terry P. Yamaguchi,Terry P. Yamaguchi,Marina Gertsenstein,Xiang-Fu Wu,Xiang-Fu Wu,Martin L. Breitman,Martin L. Breitman,Andre C. Schuh +10 more
TL;DR: The generation of mice deficient in Flk-1 by disruption of the gene using homologous recombination in embryonic stem (ES) cells is reported, indicating that FlK-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo.
Journal ArticleDOI
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Mark J. Kiel,Ömer H. Yilmaz,Toshihide Iwashita,Osman H. Yilmaz,Cox Terhorst,Sean J. Morrison +5 more
TL;DR: This work compared the gene expression profiles of highly purified HSCs and non-self-renewing multipotent hematopoietic progenitors and found that both groups occupied multiple niches, including sinusoidal endothelium in diverse tissues.
Journal ArticleDOI
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.
Birgit Millauer,Susanne Wizigmann-Voos,Harald Schnürch,Ricardo Martinez,Niels Møller,Werner Risau,Axel Ullrich +6 more
TL;DR: Investigation of flk-1 receptor tyrosine kinase mRNA expression by in situ hybridization analysis revealed specific association with endothelial cells at all stages of mouse development, suggesting a major role of this ligand-receptor signaling system in vasculogenesis and angiogenesis.
Journal ArticleDOI
Stem cells: units of development, units of regeneration, and units in evolution.
TL;DR: The review begins with a detailed examination of hematopoi-via the umbilical vein to the fetal liver between dpc 8.5 etic (blood-forming) stem cells, and the transcription pro-The earliest stem cells in ontogeny are totipotent, ex- files of each of these populations are quite distinct.
Journal ArticleDOI
Isl1 Identifies a Cardiac Progenitor Population that Proliferates Prior to Differentiation and Contributes a Majority of Cells to the Heart
Chen-Leng Cai,Xingqun Liang,Yunqing Shi,Po Hsien Chu,Samuel L. Pfaff,Ju Chen,Sylvia M. Evans +6 more
TL;DR: Two sets of cardiogenic precursors are defined, one of which expresses and requires Isl1 and the other of which does not, which have implications for the development of specific cardiac lineages, left-right asymmetry, cardiac evolution, and isolation of cardiac progenitor cells.