A
Alexandra Florescu
Researcher at McMaster University
Publications - 3
Citations - 1547
Alexandra Florescu is an academic researcher from McMaster University. The author has contributed to research in topics: Immunoglobulin E & Allergy. The author has an hindex of 2, co-authored 3 publications receiving 554 citations.
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Journal ArticleDOI
CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
Brian Alcock,Amogelang R. Raphenya,Tammy T. Y. Lau,Kara K. Tsang,Mégane Bouchard,Arman Edalatmand,William Huynh,Anna-Lisa V. Nguyen,Annie A. Cheng,Sihan Liu,Sally Y. Min,Anatoly Miroshnichenko,Hiu-Ki R Tran,Rafik El Werfalli,Jalees A. Nasir,Martins Oloni,David Speicher,Alexandra Florescu,Bhavya Singh,Mateusz Faltyn,Anastasia Hernández-Koutoucheva,Arjun N. Sharma,Emily Bordeleau,Andrew C. Pawlowski,Haley L. Zubyk,Damion M. Dooley,Emma Griffiths,Finlay Maguire,Geoffrey L. Winsor,Robert G. Beiko,Fiona S. L. Brinkman,William W. L. Hsiao,William W. L. Hsiao,Gary Van Domselaar,Gary Van Domselaar,Andrew G. McArthur +35 more
TL;DR: A new Resistomes & Variants module provides analysis and statistical summary of in silico predicted resistance variants from 82 pathogens and over 100 000 genomes, able to summarize predicted resistance using the information included in CARD, identify trends in AMR mobility and determine previously undescribed and novel resistance variants.
Journal ArticleDOI
Interrupting reactivation of immunologic memory diverts the allergic response and prevents anaphylaxis.
Kelly Bruton,Paul Spill,Shabana Vohra,Owen Baribeau,Saba Manzoor,Siyon Gadkar,Malcolm Davidson,Tina D. Walker,Joshua F E Koenig,Yosef Ellenbogen,Alexandra Florescu,Jianping Wen,Derek K. Chu,Susan Waserman,Rodrigo Jiménez-Saiz,Rodrigo Jiménez-Saiz,Slava Epelman,Clinton S. Robbins,Manel Jordana +18 more
TL;DR: In allergic mice, anti-IL-4Rα provided long-lasting suppression of the IgE recall response beyond antibody treatment and fully protected against anaphylaxis, advancing the understanding of events mediating the regeneration of IgE in food allergy.
Posted ContentDOI
Interrupting reactivation of immunological memory reprograms allergy and averts anaphylaxis
Kelly Bruton,Paul Spill,Shabana Vohra,Owen Baribeau,Saba Manzoor,Siyon Gadkar,Malcolm Davidson,Tina D. Walker,Yosef Ellenbogen,Alexandra Florescu,Jianping Wen,Derek K. Chu,Susan Waserman,Rodrigo Jiménez-Saiz,Rodrigo Jiménez-Saiz,Slava Epelman,Clinton S. Robbins,Manel Jordana +17 more
TL;DR: This investigation advances the understanding of the mechanism that regenerates IgE in food allergy and spotlights IL-4/IL-13 blockade as a therapeutic with disease-transforming potential.