A
Alexandra Irrgang
Researcher at Federal Institute for Risk Assessment
Publications - 23
Citations - 743
Alexandra Irrgang is an academic researcher from Federal Institute for Risk Assessment. The author has contributed to research in topics: Plasmid & Colistin. The author has an hindex of 11, co-authored 22 publications receiving 482 citations. Previous affiliations of Alexandra Irrgang include Free University of Berlin.
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Journal ArticleDOI
Prevalence of mcr-1 in E. coli from Livestock and Food in Germany, 2010–2015
Alexandra Irrgang,Nicole Roschanski,Bernd-Alois Tenhagen,Mirjam Grobbel,Tanja Skladnikiewicz-Ziemer,Katharina Thomas,Uwe Roesler,Annemarie Käsbohrer +7 more
TL;DR: TaqMan based real-time PCR provides a fast and accurate tool for detection of mcr-1 gene in German livestock and food isolates and indicates a worldwide spread of this newly discovered resistance gene in Enterobacteriaceae.
Journal ArticleDOI
Whole genome analyses of CMY-2-producing Escherichia coli isolates from humans, animals and food in Germany.
Michael Pietsch,Alexandra Irrgang,Nicole Roschanski,Geovana Brenner Michael,Geovana Brenner Michael,Axel Hamprecht,Heime Rieber,Annemarie Käsbohrer,Stefan Schwarz,Stefan Schwarz,Uwe Rösler,Lothar Kreienbrock,Yvonne Pfeifer,Stephan Fuchs,Guido Werner +14 more
TL;DR: Apart from the ST-driven spread, plasmid-mediated spread, especially via IncI1 and IncK plasmids, likely plays an important role for emergence and transmission of blaCMY-2 between animals and humans.
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Diversity in prevalence and characteristics of ESBL/pAmpC producing E. coli in food in Germany.
Annemarie Kaesbohrer,Karin Bakran-Lebl,Alexandra Irrgang,Jennie Fischer,Peter Kämpf,Arthur P. Schiffmann,Christiane Susanne Werckenthin,Matthias Busch,Lothar Kreienbrock,Katja Hille +9 more
TL;DR: The study results reflect that consumers might get exposed to ESBL/pAmpC-producing E. coli through several food chains, considering transmission from livestock populations to food at retail and to consumers in Germany.
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Chromosomal Locations of mcr-1 and bla CTX-M-15 in Fluoroquinolone-Resistant Escherichia coli ST410.
Linda Falgenhauer,Said-Elias Waezsada,Konrad Gwozdzinski,Hiren Ghosh,Swapnil Doijad,Boyke Bunk,Cathrin Spröer,Can Imirzalioglu,Harald Seifert,Alexandra Irrgang,Jennie Fischer,Beatriz Guerra,Annemarie Käsbohrer,Jörg Overmann,Alexander Goesmann,Trinad Chakraborty +15 more
TL;DR: The discovery of mcr-1, a plasmidborne resistance gene mediating resistance to colistin, in isolates obtained from humans and animals raises concern about the emergence of pan-resistant Enterobacteriaceae.
Journal ArticleDOI
CTX-M-15-Producing E. coli Isolates from Food Products in Germany Are Mainly Associated with an IncF-Type Plasmid and Belong to Two Predominant Clonal E. coli Lineages.
Alexandra Irrgang,Linda Falgenhauer,Jennie Fischer,Hiren Ghosh,Elisabet Guiral,Elisabet Guiral,Beatriz Guerra,Beatriz Guerra,Silvia Schmoger,Can Imirzalioglu,Trinad Chakraborty,Jens A. Hammerl,Annemarie Käsbohrer,Annemarie Käsbohrer +13 more
TL;DR: Transmission of CTX-M-15-harboring isolates from food-producing animals to food appears probable, as isolates obtained from livestock and food samples within the same time period exhibit comparable characteristics as compared to isolates detected from human.