Institution
University of Veterinary Medicine Hanover
Education•Hanover, Germany•
About: University of Veterinary Medicine Hanover is a education organization based out in Hanover, Germany. It is known for research contribution in the topics: Population & Virus. The organization has 1676 authors who have published 1722 publications receiving 43462 citations. The organization is also known as: TiHo.
Topics: Population, Virus, Glycoprotein, Lemur, Sperm
Papers published on a yearly basis
Papers
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TL;DR: Recent epidemiological data on T. gondii, hypotheses on the major routes of transmission to humans in different populations, and preventive measures that may reduce the risk of contracting a primary infection during pregnancy are presented.
3,160 citations
Flanders Marine Institute1, Australian Museum2, University of New South Wales3, University of Southern Mississippi4, National Oceanography Centre, Southampton5, University of Hasselt6, WorldFish7, American Museum of Natural History8, San Diego State University9, Museum Victoria10, Natural History Museum11, Dowling College12, University of Hamburg13, University of Johannesburg14, James Cook University15, National Museum of Natural History16, National Taiwan Ocean University17, Scripps Institution of Oceanography18, National Oceanic and Atmospheric Administration19, University of Queensland20, University of Sassari21, Université libre de Bruxelles22, Vrije Universiteit Brussel23, Queensland Museum24, University of California, Merced25, Ghent University26, Naturalis27, Howard University28, University of Gothenburg29, California Academy of Sciences30, Florida Museum of Natural History31, Centre for Environment, Fisheries and Aquaculture Science32, Osaka University33, University of Santiago de Compostela34, University of Alaska Anchorage35, University of Málaga36, National Institute of Water and Atmospheric Research37, National University of Ireland, Galway38, University of Alaska Fairbanks39, Spanish National Research Council40, CABI41, University of Siegen42, Massey University43, University of Copenhagen44, Naturhistorisches Museum45, University of Washington46, Museum für Naturkunde47, Woods Hole Oceanographic Institution48, Western Washington University49, University of Bergen50, Nova Southeastern University51, Shirshov Institute of Oceanology52, National University of Singapore53, Shimane University54, Agnes Scott College55, University of the Ryukyus56, University of California, Davis57, Federal University of Paraná58, University of the Basque Country59, University of Veterinary Medicine Hanover60, Royal Belgian Institute of Natural Sciences61, Tel Aviv University62, Swedish Museum of Natural History63, Joint Nature Conservation Committee64, The Evergreen State College65, Estonian University of Life Sciences66, University of Maine67, Virginia Commonwealth University68, Trinity College, Dublin69, University of Auckland70
TL;DR: The first register of the marine species of the world is compiled and it is estimated that between one-third and two-thirds of marine species may be undescribed, and previous estimates of there being well over one million marine species appear highly unlikely.
822 citations
TL;DR: Human fibroblasts in primary culture released reactive oxygen species upon stimulation with cytokines such as interleukin-1 alpha (IL-1) or tumour necrosis factor-alpha (TNF) as determined by e.r.s. spin trapping and cytochrome c reduction.
Abstract: Human fibroblasts in primary culture released reactive oxygen species upon stimulation with cytokines such as interleukin-1 alpha (IL-1) or tumour necrosis factor-alpha (TNF) The primary radical produced was O2- as determined by esr spin trapping and cytochrome c reduction In contrast to the oxidative burst in granulocytes and monocytes, radical formation took place continuously for at least 4 h Low-level chemiluminescence was increased by stimulation with IL-1 and TNF Spectral characteristics and tests with azide led to the conclusion that the photoemissive species were excited carbonyls and not singlet oxygen Further, there was a liberation of ethane from the cells Radical production and light emission were not altered by either xanthine or allopurinol, nor by azide, cyanide or rotenone O2- production increased in the presence of NADH or NADPH, making an NAD(P)H oxidase a likely source
639 citations
TL;DR: In this paper, the authors measured ammonia and carbon dioxide (the latter for estimating ventilation rates) at seven locations inside and one location outside in four replicates of each housing type over 24h under summer and winter conditions.
476 citations
TL;DR: Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases.
Abstract: Coronaviruses (CoVs) are important human and animal pathogens that induce fatal respiratory, gastrointestinal and neurological disease. The outbreak of the severe acute respiratory syndrome (SARS) in 2002/2003 has demonstrated human vulnerability to (Coronavirus) CoV epidemics. Neither vaccines nor therapeutics are available against human and animal CoVs. Knowledge of host cell proteins that take part in pivotal virus-host interactions could define broad-spectrum antiviral targets. In this study, we used a systems biology approach employing a genome-wide yeast-two hybrid interaction screen to identify immunopilins (PPIA, PPIB, PPIH, PPIG, FKBP1A, FKBP1B) as interaction partners of the CoV non-structural protein 1 (Nsp1). These molecules modulate the Calcineurin/NFAT pathway that plays an important role in immune cell activation. Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases. Conversely, inhibition of cyclophilins by cyclosporine A (CspA) blocked the replication of CoVs of all genera, including SARS-CoV, human CoV-229E and -NL-63, feline CoV, as well as avian infectious bronchitis virus. Non-immunosuppressive derivatives of CspA might serve as broad-range CoV inhibitors applicable against emerging CoVs as well as ubiquitous pathogens of humans and livestock.
381 citations
Authors
Showing all 1685 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Albert D. M. E. Osterhaus | 124 | 955 | 83678 |
| Bruce D. Hammock | 111 | 1409 | 57401 |
| Peter F. Stadler | 103 | 901 | 56813 |
| Wolfgang Löscher | 82 | 347 | 25535 |
| Juan J. Calvete | 81 | 458 | 22646 |
| Jürgen Soll | 72 | 224 | 14663 |
| Michael S. McLachlan | 60 | 209 | 10389 |
| Ulrich Kalinke | 60 | 233 | 15171 |
| Heinz Nau | 57 | 223 | 10426 |
| Michael Schemann | 54 | 230 | 9578 |
| Heidrun Potschka | 51 | 194 | 9701 |
| Anne K. Voss | 49 | 110 | 6702 |
| Konrad Sachse | 49 | 197 | 7289 |
| Ursula Siebert | 48 | 350 | 7559 |
| Jörn Bullerdiek | 48 | 339 | 9372 |