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Alexandra Stubelius
Researcher at University of Gothenburg
Publications - 36
Citations - 963
Alexandra Stubelius is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Arthritis & Estrogen. The author has an hindex of 15, co-authored 30 publications receiving 665 citations. Previous affiliations of Alexandra Stubelius include Sahlgrenska University Hospital & University of Montana.
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Journal ArticleDOI
Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production.
Elsa Sanchez-Lopez,Zhenyu Zhong,Zhenyu Zhong,Alexandra Stubelius,Shannon R. Sweeney,Laela M. Booshehri,Laura Antonucci,Ru Liu-Bryan,Alessia Lodi,Robert Terkeltaub,Juan Carlos Lacal,Anne N. Murphy,Hal M. Hoffman,Stefano Tiziani,Monica Guma,Michael Karin +15 more
TL;DR: It is found that Toll-like receptor (TLR) activation enhances choline uptake by macrophages and microglia through induction of the choline transporter CTL1, and choline kinase inhibitors ameliorated acute and chronic models of IL-1β-dependent inflammation.
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The Chemistry of Boronic Acids in Nanomaterials for Drug Delivery.
TL;DR: Both materials functionalized with BA and boronic esters display good safety profiles in vitro and in vivo; thus, BA-containing materials represent promising carriers for responsive delivery systems with great potential for clinical translation.
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Roles of transactivating functions 1 and 2 of estrogen receptor-α in bone
Anna E Börjesson,Sara H Windahl,Marie K Lagerquist,Cecilia Engdahl,Baruch Frenkel,Sofia Movérare-Skrtic,Klara Sjögren,Jenny M. Kindblom,Alexandra Stubelius,Ulrika Islander,Maria Cristina Antal,Andrée Krust,Pierre Chambon,Claes Ohlsson +13 more
TL;DR: Estradiol treatment increased the amount of both trabecular and cortical bone in ovariectomized (OVX) WT mice and the effect of E2 in OVX ERαAF-10 mice was tissue-dependent, with no or weak E2 response on thymus and uterine weights but a normal response on liver weight.
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Inflammation-responsive Drug-conjugated Dextran Nanoparticles Enhance Anti-inflammatory Drug Efficacy
TL;DR: It is believed that drug conjugation using PBA can be applied to various drugs and dextran-based materials for enhanced drug efficacy, where this work demonstrates the significance of functionalized carbohydrates polymer-drug conjugates.
Journal ArticleDOI
Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune arthritis.
Annica Andersson,Alexandra Stubelius,Merja Nurkkala Karlsson,Cecilia Engdahl,Malin C. Erlandsson,Louise Grahnemo,Marie K Lagerquist,Ulrika Islander +7 more
TL;DR: E2 treatment results in an increase in Th17 cells in lymph nodes during the early phase of arthritis development, but leads to a decrease of Th17 in joints during established arthritis, suggesting that this may be caused by interference with the CCR6-CCL20 pathway, which is important for Th17 cell migration.