S
Stefano Tiziani
Researcher at University of Texas at Austin
Publications - 96
Citations - 3853
Stefano Tiziani is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 27, co-authored 76 publications receiving 2745 citations. Previous affiliations of Stefano Tiziani include Sanford-Burnham Institute for Medical Research & University of Trieste.
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Journal ArticleDOI
An inhibitor of oxidative phosphorylation exploits cancer vulnerability.
Jennifer R. Molina,Yuting Sun,Marina Protopopova,Sonal Gera,Madhavi Bandi,Christopher A. Bristow,Timothy McAfoos,Pietro Morlacchi,Pietro Morlacchi,Jeffrey J. Ackroyd,Ahmed Noor A. Agip,Gheath Alatrash,John M. Asara,Jennifer Bardenhagen,Caroline C. Carrillo,Christopher Carroll,Edward F. Chang,Stefan O. Ciurea,Cross Jason,Barbara Czako,Angela K. Deem,Naval Daver,John de Groot,Jian Wen Dong,Ningping Feng,Guang Gao,Mary Geck Do,Jennifer Greer,Virginia Giuliani,Jing Han,Lina Han,Verlene Henry,Judy Hirst,Sha Huang,Yongying Jiang,Zhijun Kang,Tin Oo Khor,Sergej Konoplev,Yu Hsi Lin,Gang Liu,Alessia Lodi,Timothy Lofton,Helen Ma,Mikhila Mahendra,Polina Matre,Robert A. Mullinax,Michael Peoples,Alessia Petrocchi,Jaime Rodriguez-Canale,Riccardo Serreli,Thomas Shi,Melinda Smith,Yoko Tabe,Yoko Tabe,Jay Theroff,Stefano Tiziani,Quanyun Xu,Qi Zhang,Florian L. Muller,Ronald A. DePinho,Carlo Toniatti,Giulio Draetta,Timothy P. Heffernan,Marina Konopleva,Philip Jones,M. Emilia Di Francesco,Joseph R. Marszalek +66 more
TL;DR: Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis.
Journal ArticleDOI
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
Shira L. Cramer,Achinto Saha,Jinyun Liu,Surendar Tadi,Stefano Tiziani,Wupeng Yan,Kendra Triplett,Candice Lamb,Susan E. Alters,Scott W. Rowlinson,Yan Jessie Zhang,Michael J. Keating,Peng Huang,John DiGiovanni,George Georgiou,Everett Stone +15 more
TL;DR: It was observed that enzyme-mediated depletion of the serum L-Cys and CSSC pool suppresses the growth of multiple tumors, yet is very well tolerated for prolonged periods, suggesting that cyst(e)inase represents a safe and effective therapeutic modality for inactivating antioxidant cellular responses in a wide range of malignancies.
Journal ArticleDOI
Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics
TL;DR: The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors, which suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis.
Journal ArticleDOI
Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis.
Jane Falconer,Anne N. Murphy,Stephen P. Young,Andrew R. Clark,Stefano Tiziani,Monica Guma,Christopher D. Buckley,Christopher D. Buckley +7 more
TL;DR: It is not yet known whether metabolic change is a consequence of disease or whether primary changes to cellular metabolism might underlie or contribute to the pathogenesis of early‐stage disease.
Journal ArticleDOI
Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes
Ricard Garcia-Carbonell,Ajit S. Divakaruni,Alessia Lodi,Ildefonso Vicente-Suarez,Arindam Saha,Hilde Cheroutre,Gerry R. Boss,Stefano Tiziani,Anne N. Murphy,Monica Guma +9 more
TL;DR: This study evaluated whether changes in glucose metabolism in RA FLS could play a role in inflammation and joint damage.