A
Alexandra V. Maleeva
Publications - 6
Citations - 240
Alexandra V. Maleeva is an academic researcher. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 3, co-authored 5 publications receiving 123 citations.
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Journal ArticleDOI
SARS-CoV-2 Epitopes Are Recognized by a Public and Diverse Repertoire of Human T Cell Receptors.
Alina S. Shomuradova,Murad Vagida,Savely A. Sheetikov,Ksenia V. Zornikova,Dmitry Kiryukhin,Aleksei Titov,Iuliia O. Peshkova,Alexandra Khmelevskaya,Dmitry Vladimirovich Dianov,Maria Malasheva,Anton Shmelev,Yana Serdyuk,Dmitry V. Bagaev,Anastasia Pivnyuk,Dmitrii S. Shcherbinin,Alexandra V. Maleeva,Naina T. Shakirova,Artem Pilunov,Dmitry B. Malko,Ekaterina G. Khamaganova,Bella Biderman,Alexander V. Ivanov,Mikhail Shugay,Grigory A. Efimov +23 more
TL;DR: The results demonstrate that the T cell response to SARS-CoV-2, including the identified set of TCRs, can serve as a useful biomarker for surveying antiviral immunity.
Posted ContentDOI
SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T-cell receptors
Alina S. Shomuradova,Murad Vagida,Savely A. Sheetikov,Ksenia V. Zornikova,Dmitry Kiryukhin,Aleksei Titov,Iuliia O. Peshkova,Alexandra Khmelevskaya,Dmitry Vladimirovich Dianov,Maria Malasheva,Anton Shmelev,Yana Serdyuk,Dmitry V. Bagaev,Anastasia Pivnyuk,Dmitrii S. Shcherbinin,Alexandra V. Maleeva,Naina T. Shakirova,Artem Pilunov,Dmitry B. Malko,Ekaterina G. Khamaganova,Bella Biderman,Alexander V. Ivanov,Mikhail Shugay,Grigory A. Efimov +23 more
TL;DR: It is indicated that T cells form an efficient response to Sars-CoV-2 and alongside the antibodies can serve as a useful biomarker for surveying SARS-Cov-2 exposure and immunity.
Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study
Ivan Molodtsov,Evgenii Kegeles,Alexander N Mitin,Olga N. Mityaeva,O. E. Musatova,Anna Panova,Mikhail Pashenkov,Iuliia O. Peshkova,A. Alsalloum,Walaa Asaad,Anna S. Budikhina,Alexander S Deryabin,Inna V. Dolzhikova,Ioanna N. Filimonova,A. N. Gracheva,O. Ivanova,Anastasia Kizilova,Viktoria Komogorova,Anastasia Komova,N. Kompantseva,E. G. Kucheryavykh,Denis A Lagutkin,Yakov A. Lomakin,Alexandra V. Maleeva,E. Maryukhnich,Afra Hammad Mohammad,Vladimir V. Murugin,Nina E. Murugina,A. Navoikova,M.F Nikonova,Leyla A. Ovchinnikova,Yana Panarina,Natalia V Pinegina,D. Potashnikova,Elizaveta V. Romanova,Aleena A. Saidova,Nawar Sakr,Anastasia Samoilova,Yana Serdyuk,Naina T. Shakirova,Nina I. Sharova,S. A. Sheetikov,Anastasia F Shemetova,L. Shevkova,Alexander Shpektor,A. A. Trufanova,Anna V. Tvorogova,V. M. Ukrainskaya,A. S. Vinokurov,Daria A Vorobyeva,Ksenia V. Zornikova,Grigory A. Efimov,Musa Khaitov,I. A. Kofiadi,Alexey A. Komissarov,Denis Y. Logunov,N. B. Naigovzina,Yury P. Rubtsov,Irina Vasilyeva,Pavel Volchkov,Elena Vasilieva +60 more
TL;DR: In a prospective study involving 5340 individuals, humoral and cellular responses revealed magnitude-dependent protection from COVID-19; Antibodies alone significantly decreased infection rates; isolated cellular response provided an intermediate level of protection.
Posted ContentDOI
A prospective study of the protective effect of SARS-CoV-2-specific antibodies and T cells in Moscow residents
Ivan Molodtsov,Evgenii Kegeles,Alexander Mitin,Olga Mityaeva,Oksana Musatova,Anna Panova,Mikhail Pashenkov,Iuliia O. Peshkova,Alsalloum Almaqdad,Walaa Asaad,Anna Budikhina,Aleksander Deryabin,Inna V. Dolzhikova,Ioanna N. Filimonova,Alexandra Gracheva,O. Ivanova,Anastasia Kizilova,Viktoria Komogorova,Anastasia Komova,Natalia Kompantseva,Denis Lagutkin,Yakov A. Lomakin,Alexandra V. Maleeva,E. Maryukhnich,Afraa Mohammad,Vladimir Murugin,Nina Murugina,Anna Navoikova,Margarita Nikonova,Leila Ovchinnikova,N. Pinegina,Daria Potashnikova,Elizaveta Romanova,Aleena Saidova,Nawar Sakr,Anastasia Samoilova,Yana Serdyuk,Naina T. Shakirova,Nina Sharova,Savely A. Sheetikov,Anastasia Shemetova,Liudmila Shevkova,Alexander Shpektor,Anna Trufanova,Anna Tvorogova,V. M. Ukrainskaya,Anatoliy Vinokurov,D. Vorobyeva,Ksenia V. Zornikova,Grigory A. Efimov,Musa Khaitov,Ilya Kofiadi,Alexey A. Komissarov,Denis Y. Logunov,Nelli B. Naigovzina,Yury P. Rubtsov,Irina Vasilyeva,Pavel Volchkov,Elena Vasilieva +58 more
TL;DR: In this paper, the authors evaluated the anti-SARS-CoV-2 IgM/IgG titers and the frequencies of the T cells specific to the nucleocapsid, membrane, and spike proteins of SARS CoV2, using IFNγ ELISpot, and also evaluated the fractions of virus-specific CD4+ and CD8+ T cells using intracellular staining of IFNsγ and IL2 followed by flow cytometry.
Journal ArticleDOI
SARS-CoV-2 Epitopes are Recognized by a Public and Diverse Repertoire of Human T-Cell Receptors
Alina S. Shomuradova,Murad Vagida,Savely A. Sheetikov,Ksenia V. Zornikova,Dmitry Kiryukhin,Aleksei Titov,Iuliia O. Peshkova,Alexandra Khmelevskaya,Dmitry Vladimirovich Dianov,Maria Malasheva,Anton Shmelev,Yana Serdyuk,Dmitry V. Bagaev,Anastasia Pivnyuk,Dmitrii S. Shcherbinin,Alexandra V. Maleeva,Naina T. Shakirova,Artem Pilunov,Dmitry B. Malko,Ekaterina G. Khamaganova,Bella Biderman,Alexander V. Ivanov,Mikhail Shugay +22 more
TL;DR: Shugay et al. as discussed by the authors assessed the antibody and T-cell reactivity in COVID-19 convalescent patients and healthy donors sampled both prior to and during the pandemic.