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Alexandre B. M. da Silveira
Researcher at Federal University of Uberlandia
Publications - 23
Citations - 560
Alexandre B. M. da Silveira is an academic researcher from Federal University of Uberlandia. The author has contributed to research in topics: Megacolon & Enteric nervous system. The author has an hindex of 13, co-authored 23 publications receiving 511 citations. Previous affiliations of Alexandre B. M. da Silveira include Oswaldo Cruz Foundation & Universidade Federal de Minas Gerais.
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Journal ArticleDOI
Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells
Alexandre B. M. da Silveira,Elenice Moreira Lemos,Sheila Jorge Adad,Rodrigo Correa-Oliveira,John B. Furness,Débora d'Ávila Reis +5 more
TL;DR: Development of megacolon after acute infection with T cruzi is associated with maintained invasion of enteric ganglia with cytotoxic T cells and loss of muscle innervation, but changes in glial cell numbers are not associated with progression ofEnteric neuropathy.
Journal ArticleDOI
Cellular and genetic mechanisms involved in the generation of protective and pathogenic immune responses in human Chagas disease
Walderez O. Dutra,Cristiane Alves da Silva Menezes,Fernanda Nobre Amaral Villani,Germano C. Costa,Alexandre B. M. da Silveira,Débora d'Ávila Reis,Kenneth J. Gollob +6 more
TL;DR: It is believed that now, one hundred years after the discovery of Chagas disease, it is imperative to continue with highly interactive research in order to elucidate the immune response associated with disease evolution, which will be essential in designing prophylactic or therapeutic interventions.
Journal ArticleDOI
Chagasic megacolon: enteric neurons and related structures
TL;DR: Neurons co-immunoreactive for VIP and calretinin survived disproportionately and may have contributed to maintain the epithelial barrier and allowed the chagasic patients to survive for decades, despite their severe disturbance of colonic motility.
Journal ArticleDOI
Enteroglial cells act as antigen-presenting cells in chagasic megacolon.
Alexandre B. M. da Silveira,Alexandre B. M. da Silveira,Enio Chaves de Oliveira,Salustiano Gabriel Neto,Alejandro O. Luquetti,Ricardo Toshio Fujiwara,Ricardo Toshio Fujiwara,Rodrigo Corrêa Oliveira,Axel Brehmer +8 more
TL;DR: The results indicate that only enteric glial cells of chagasic patients with megacolon express HLA-DR complex class II and costimulatory molecules, and hence they present the attributes necessary to act as antigen-presenting cells.
Journal ArticleDOI
Glial fibrillary acidic protein and S-100 colocalization in the enteroglial cells in dilated and nondilated portions of colon from chagasic patients
Alexandre B. M. da Silveira,Michelle A. R. Freitas,Enio Chaves de Oliveira,Salustiano Gabriel Neto,Alejandro O. Luquetti,John B. Furness,Rodrigo Correa-Oliveira,Débora d'Ávila Reis +7 more
TL;DR: The results suggest that glial fibrillary acidic protein enteric glial cells prevent dilatation of the organ and protect the enteric nervous system against the inflammatory process and neuronal destruction, preventing the destruction from expanding to unaffected areas of the colon.