Showing papers in "Human Pathology in 2007"

TL;DR: It is found that high PSMA levels were associated with significant increase of PSA recurrence in a high-risk cohort and thus might provide insight into the additional use of adjuvant therapy.

TL;DR: The fact that pulmonary arterial hypertension complicating the course of connective tissue diseases may be characterized by a more frequent involvement of pulmonary veins is highlighted and may explain why these patients are less prone to respond to specific pulmonary arterials hypertension treatment as compared with idiopathic pulmonary arterIAL hypertension.

TL;DR: Although much speculation exists that VUE represents a host-versus-graft reaction analogous to transplant rejection, other eliciting antigens have not been excluded and the pathophysiologic implications of having activated maternal lymphocytes within vascularized fetal tissues are not trivial.

TL;DR: A review of EBV-associated lymphoproliferative disorders, dividing them into B-cell, T/NK-cell and HIV-related lymphoplastic disorders, is presented in this article.

TL;DR: These studies demonstrate the presence of a basal-like in situ carcinoma, a potential precursor lesion to invasive basal- like carcinoma.

TL;DR: Observations provide the first functional evidence that mTOR activation is common to sporadic, non-TSC-related AMLs and PEComas, and suggests the possibility that m TOR inhibitors such as rapamycin may be therapeutic for this class of disease.

TL;DR: It is confirmed that GRP78 protein expression is significantly higher in prostate cancer than in benign prostatic tissue and the intensity of expression is significant associated with survival and clinical recurrence.

TL;DR: In this paper, the authors reviewed morphological and pathophysiological features of some of the more common and pathologically recognizable drug-related injury patterns and provided a practical guide for the recognition and diagnosis of drug-induced pathology in the upper and lower GI tract.

TL;DR: In this paper, the authors investigated 930 breast carcinomas categorized according to patients' survival using automated immunohistochemical procedures (Ventana, Cedex, France) with tissue microarrays and quantification of immunoprecipitates assessed by automated image analysis densitometry.

TL;DR: Apoptosis may play a role in the pathogenesis of SARS associated coronavirus infection in the thyroid gland and may provide an explanation both for low serum triiodothyronine and thyroxine levels and the osteonecrosis of the femoral head associated with patients with SARS.

TL;DR: A detailed cytomorphologic evaluation of the circulating component of widely metastatic breast carcinoma of a previously healthy 38-year-old woman finds that the patient's CTCs exhibit a high degree of pleomorphism including C TCs with high and low nuclear-to-cytoplasmic ratios along with CTCS exhibiting early and late apoptotic changes.

TL;DR: It is becoming evident that alternative approaches to direct KIT inhibition will be required for long-term survival of patients with advanced GISTs, and Sunitinib has recently been approved for patients with GIST; and additional small molecule inhibitors are in the pipeline.

TL;DR: The data suggest that the Wnt signaling pathway may be abnormally regulated in NPC, which provides insight into the molecular mechanisms of NPC.

TL;DR: A critical review of all of the information that is presently available on those markers that are believed to have the greatest potential for assisting in distinguishing between epithelioid mesotheliomas and those carcinomas with which they are most likely to be confused is provided.

TL;DR: A strong association between FEA and ADH is found, which may reflect a biologic progression and should be recognized and warrants a follow-up excision.

TL;DR: Immunohistochemical expression and prognostic significance of claudins are variable in PACs, with decreased expression ofClaudin-1 emerging as an independent prognostic variable warranting further study.

TL;DR: Development of megacolon after acute infection with T cruzi is associated with maintained invasion of enteric ganglia with cytotoxic T cells and loss of muscle innervation, but changes in glial cell numbers are not associated with progression ofEnteric neuropathy.

TL;DR: The first case of intracranial inflammatory pseudotumor shown to be associated with IgG4-related systemic disease is presented, a 77-year-old Chinese man with a pituitary tumor diagnosed histopathologically.

TL;DR: HNF-1beta would be an excellent marker for distinguishing CCAs from other lesions in both the ovary and the endometrium and seems to be associated with physiopathological cytoplasmic glycogen accumulation in these organs.

TL;DR: Determination of eotaxin-3 levels by real-time polymerase chain reaction on paraffinized, formalin-fixed tissue may be a useful test in the differentiation of eosinophilic esophagitis from gastroesophageal reflux disease.

TL;DR: Increased TWIST expression in bladder cancer specimens was correlated with decreased membranous expression of E-cadherin, a cell adhesion molecule that plays a key role in the metastatic progression of human cancer.

TL;DR: Measurements of Her-2 expression by FISH and real-time q-PCR and of HER-2 protein by IHC were found to be highly concordant at determining her-2 status in gastric carcinoma.

TL;DR: A significant positive correlation between the macroscopic extent of lung fibrosis and mean pulmonary artery pressure is found, but it is found that in many patients with IPF, nonfibrotic lung areas demonstrate an occlusive venopathy, the signification of which remains undetermined.

TL;DR: Women with EC/CC had significantly better overall survival (P = .0008), and this remained significant after accounting for stage (P=.04).

TL;DR: Quantitation of reactive stroma and recognition of the stromogenic carcinoma in H&E-stained biopsies is useful to predict biochemical recurrence in prostate carcinoma patients independent of Gleason grade and prostate-specific antigen.

TL;DR: Treatment was similar in both groups, but neck dissection was performed more frequently in patients with TCV, and it is a more aggressive form of PTC than CF because of the higher stage and increased grade.

TL;DR: Results show that the HIF-alpha subunit represents an important biomarker in the evaluation of the prognosis of patients with ovarian carcinoma and that the nuclear expression of Hif-1alpha is an independent prognostic factor.

TL;DR: Tumor cells of all cases of both angioleiomyomas and myopericytomas were diffusely positive for actins (alpha-smooth muscle actin and HHF35) and calponin, and all cases, except for 1 my opericytoma, were also diffusely or focally positive for h-caldesmon.

TL;DR: The utility of FISH for the detection of bladder, lung, pancreatobiliary, and esophageal carcinoma in cytologic specimens is discussed.

TL;DR: The results indicated that CXC chemokines might contribute to the progression of ovarian carcinomas and endometriosis in different manners.