Journal ArticleDOI
Megacolon in Chagas disease: a study of inflammatory cells, enteric nerves, and glial cells
Alexandre B. M. da Silveira,Elenice Moreira Lemos,Sheila Jorge Adad,Rodrigo Correa-Oliveira,John B. Furness,Débora d'Ávila Reis +5 more
TLDR
Development of megacolon after acute infection with T cruzi is associated with maintained invasion of enteric ganglia with cytotoxic T cells and loss of muscle innervation, but changes in glial cell numbers are not associated with progression ofEnteric neuropathy.About:
This article is published in Human Pathology.The article was published on 2007-08-01. It has received 135 citations till now. The article focuses on the topics: Enteric neuropathy & Megacolon.read more
Citations
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Journal ArticleDOI
The involvement of nitric oxide synthase neurons in enteric neuropathies
TL;DR: Nitric oxide (NO), produced by the neural nitric oxide synthase enzyme (nNOS) is a transmitter of inhibitory neurons supplying the muscle of the gastrointestinal tract, which is necessary for sphincter relaxation that allows the passage of gut contents, and for relaxation of muscle during propulsive activity in the colon.
Journal ArticleDOI
Current concepts in immunoregulation and pathology of human Chagas disease.
TL;DR: Several theories exist to explain differential clinical evolution of Chagas disease and a coherent understanding of these theories will certainly aid in determining what combination of them approximates the true development of chagasic pathology.
Journal ArticleDOI
The chronic gastrointestinal manifestations of Chagas disease
TL;DR: The objective of this review is to revise the literature and summarize the main chronic gastrointestinal manifestations of Chagas disease.
Journal ArticleDOI
Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence
TL;DR: Recent observations indicate that T. cruzi invades host cells by subverting a highly conserved cellular pathway for the repair of plasma membrane lesions, suggesting that the mechanism used by the parasites for cell invasion may be a primary determinant of tissue tropism, intracellular persistence, and Chagas' disease pathology.
Journal ArticleDOI
White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies
Alan J. Burns,Alan J. Burns,Allan M. Goldstein,Donald F. Newgreen,Lincon A. Stamp,Karl-Herbert Schäfer,Marco Metzger,Ryo Hotta,Heather M. Young,Peter W. Andrews,Nikhil Thapar,Jaime Belkind-Gerson,Nadege Bondurand,Joel C. Bornstein,Wood Yee Chan,Kathryn S.E. Cheah,Michael D. Gershon,Robert O. Heuckeroth,Robert M.W. Hofstra,Lothar Just,Raj P. Kapur,Sebastian K. King,Conor J. McCann,Nandor Nagy,Elly Sau-Wai Ngan,Florian Obermayr,Vassilis Pachnis,Pankaj J. Pasricha,Mai Har Sham,Paul K.H. Tam,Pieter Vanden Berghe +30 more
TL;DR: Experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function are set out.
References
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Journal ArticleDOI
The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase
Keith D. Wilkinson,Keunmyoung Lee,Seema S. Deshpande,Penelope J. Duerksen-Hughes,Jeremy M. Boss,Jan Pohl +5 more
TL;DR: A complementary DNA (cDNA) for ubiquitin carboxyl-terminal hydrolase isozyme L3 was cloned from human B cells, suggesting that a family of such related proteins exists and that their expression is tissue-specific.
Journal ArticleDOI
Clinical and epidemiological aspects of Chagas disease
TL;DR: The indeterminate clinical form of Chagas disease, despite its good prognosis on at least a medium-term basis (5-10 years), has acquired increasing importance due to the controversial meaning of the abnormality of some tests and the myocardial focal lesions found in many patients.
Journal ArticleDOI
Fulminant Jejuno-Ileitis following Ablation of Enteric Glia in Adult Transgenic Mice
Toby G Bush,Tor C. Savidge,Tor C. Savidge,Tom C. Freeman,Hilary Cox,Elizabeth A. Campbell,Lennart Mucke,Martin H. Johnson,Michael V. Sofroniew,Michael V. Sofroniew +9 more
TL;DR: It is suggested that enteric glia play an essential role in maintaining the integrity of the bowel and suggest that their loss or dysfunction may contribute to the cellular mechanisms of inflammatory bowel disease.
Book ChapterDOI
Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis.
TL;DR: American trypanosomiasis shows a very peculiar pathology of homeostasis of the human organism, and represents even today a new realm in pathology, which becomes understandable through Cannon's law of denervation.
Journal ArticleDOI
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.
TL;DR: The recent discovery that brain PGP 9.5 is a ubiquitin carboxyl‐terminal hydrolase suggests that the role of this protein should be studied in relation to ubiquitinated cellular inclusions characteristic of several chronic human degenerative diseases.