Alexandre Philips

TL;DR: In this paper, a single amino acid substitution in the enzyme was found in ten highly resistant strains of Culex pipiens from tropical (Africa and Caribbean) and temperate (Europe) areas, as well as in one resistant African strain of A. gambiae.

TL;DR: The in vivo signaling function of Nur77 appears to be mediated by dimers acting on a palindromic response element of unusual spacing between its half-sites, which may represent the biologically relevant paradigm of action for this subfamily of orphan nuclear receptors.

TL;DR: Gc antagonism of NurRE activity was observed in response to physiological stimuli in both endocrine (CRH induction of POMC) and lymphoid (T-cell receptor activation) cells, and in transfection experiments, transcriptional activation by Nur77 and the repressor activity of liganded GR titrated each other on their cognate DNA target.

TL;DR: It is shown that the ERK5 cascade, a distinct mitogen-induced MAPK pathway, can also drive cyclin D1 expression and is identified as a novel target of the EMT cascade, an observation with important implications in cancers involving cyclIn D1 deregulation.

TL;DR: A new regulatory module is identified that controls repression of G1‐specific genes in G0/G1 and it is identified as CERC, a novel bipartite repressor element located near the cyclin E transcription start site.