Journal ArticleDOI
Comparative genomics: Insecticide resistance in mosquito vectors.
Mylène Weill,Georges Lutfalla,Knud Erik Mogensen,Fabrice Chandre,Arnaud Berthomieu,Claire Berticat,Nicole Pasteur,Alexandre Philips,Philippe Fort,Michel Raymond +9 more
TLDR
In this paper, a single amino acid substitution in the enzyme was found in ten highly resistant strains of Culex pipiens from tropical (Africa and Caribbean) and temperate (Europe) areas, as well as in one resistant African strain of A. gambiae.Abstract:
Resistance to insecticides among mosquitoes that act as vectors for malaria (Anopheles gambiae) and West Nile virus (Culex pipiens) emerged more than 25 years ago in Africa, America and Europe; this resistance is frequently due to a loss of sensitivity of the insect's acetylcholinesterase enzyme to organophosphates and carbamates1. Here we show that this insensitivity results from a single amino-acid substitution in the enzyme, which we found in ten highly resistant strains of C. pipiens from tropical (Africa and Caribbean) and temperate (Europe) areas, as well as in one resistant African strain of A. gambiae. Our identification of this mutation may pave the way for designing new insecticides.read more
Citations
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Stretchable form of single crystal silicon for high performance electronics on rubber substrates
TL;DR: In this article, the authors present stretchable and printable semiconductors and electronic circuits capable of providing good performance when stretched, compressed, flexed, or otherwise deformed.
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Amorphous Oxide Semiconductors for High-Performance Flexible Thin-Film Transistors
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The molecular basis of insecticide resistance in mosquitoes.
TL;DR: This paper reviews what is currently known about insecticide resistance conferred by metabolic or target site changes in mosquitoes.
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The locus of evolution: evo devo and the genetics of adaptation
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The Loci of Evolution: How Predictable is Genetic Evolution?
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References
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Journal ArticleDOI
Resistance-associated point mutations in insecticide-insensitive acetylcholinesterase
TL;DR: The sequence analysis of the Ace gene in several resistant field strains of Drosophila melanogaster resulted in the identification of five point mutations associated with reduced sensitivities to insecticides, suggesting that recombination between resistant alleles preexisting in natural populations is a mechanism by which insects rapidly adapt to new selective pressures.
Journal ArticleDOI
Control of phlebotomine sandflies.
B. Alexander,Michele Maroli +1 more
TL;DR: Control measures that act specifically against immatures are not feasible, although the effectiveness of a few biological and chemical agents has been demonstrated in laboratory evaluations.
Journal ArticleDOI
A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non-homologous to the ace gene in Drosophila.
Mylène Weill,Philippe Fort,Arnaud Berthomieu,Marie Pierre Dubois,Nicole Pasteur,Michel Raymond +5 more
TL;DR: Two AChE loci are identified in the genome of Anopheles gambiae, one (ACE–1) being a new locus and the other (ace–2) being homologous to the gene previously described in Drosophila, indicating the existence of a second ace locus.
Journal ArticleDOI
Insect acetylcholinesterase: catalytic properties, tissue distribution and molecular forms.
TL;DR: In this paper, the authors propose a method to identify the root cause of a problem.Abbreviations: [2]... ].., [3]
Journal ArticleDOI
Determination of Ace.1 Genotypes in Single Mosquitoes: Toward an Ecumenical Biochemical Test
TL;DR: A new rapid microplate test that allows unambiguous identification of Ace.1 genotypes can be misclassified by previous tests is described, and the similarity of propoxur sensitivity of modified AChE1s found in various resistant strains from the United States, Europe, and Africa indicates that this test is probably suitable for all the Ace.