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Alexei A. Neverov
Researcher at Queen's University
Publications - 61
Citations - 1435
Alexei A. Neverov is an academic researcher from Queen's University. The author has contributed to research in topics: Catalysis & Methoxide. The author has an hindex of 26, co-authored 61 publications receiving 1374 citations.
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Journal ArticleDOI
Substituent Effects on the [N–I–N]+ Halogen Bond
Anna-Carin C. Carlsson,Krenare Mehmeti,Martin Uhrbom,Alavi Karim,Michele Bedin,Rakesh Puttreddy,Roland Kleinmaier,Alexei A. Neverov,Bijan Nekoueishahraki,Jürgen Gräfenstein,Kari Rissanen,Máté Erdélyi +11 more
TL;DR: Isotopic perturbation of equilibrium NMR studies along with computation on the DFT level indicate that all studied systems possess static, symmetric [N–I–N]+ halogen bonds, independent of their electron density.
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Combination of a Dinuclear Zn2+ Complex and a Medium Effect Exerts a 1012-Fold Rate Enhancement of Cleavage of an RNA and DNA Model System
Alexei A. Neverov,Zhong-Lin Lu,Christopher I. Maxwell,Mark F. Mohamed,Christopher J. White,Josephine S. W. Tsang,R. Stan Brown +6 more
TL;DR: The study shows that a simple model system comprising a dinuclear Zn2+ complex and a medium effect of the alcohol solvent achieves a catalytic reactivity that approaches enzymatic rates and is well beyond anything seen to date in water for the cleavage of these phosphate diesters.
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Mechanistic studies of La3+- and Zn2+-catalyzed methanolysis of aryl phosphate and phosphorothioate triesters. Development of artificial phosphotriesterase systems
TL;DR: The kinetic data for the metal-catalyzed reactions are analyzed in terms of a common mechanism where there is extensive cleavage of the P-XAr bond in the rate-limiting transition state.
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Potentiometric titration of metal ions in methanol
TL;DR: In this paper, the titration profiles were analyzed using a commercially available fitting program to obtain information about the species present in solution, including La3+ for which a dimer model was proposed.
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Dinuclear Zn(II) catalysts as biomimics of RNA and DNA phosphoryl transfer enzymes: changing the medium from water to alcohol provides enzyme‐like rate enhancements
TL;DR: In this paper, the authors describe how a simple mononuclear and a dinuclear Zn(II) complex promoted the cleavage of a series of RNA models and DNA models in methanol and ethanol media.