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Alexis J. Carulli
Researcher at University of Michigan
Publications - 9
Citations - 942
Alexis J. Carulli is an academic researcher from University of Michigan. The author has contributed to research in topics: Notch signaling pathway & Progenitor cell. The author has an hindex of 6, co-authored 9 publications receiving 797 citations.
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Journal ArticleDOI
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
Kelli L. VanDussen,Alexis J. Carulli,Theresa M. Keeley,Sanjeevkumar R. Patel,Brent J. Puthoff,Scott T. Magness,Ivy T. Tran,Ivan Maillard,Christian W. Siebel,Åsa Kolterud,Ann S. Grosse,Deborah L. Gumucio,Stephen A. Ernst,Yu Hwai Tsai,Peter J. Dempsey,Linda C. Samuelson +15 more
TL;DR: It is shown in mice that Notch directly targets the crypt base columnar (CBC) cell to maintain stem cell activity and to regulate cell fate choice to control epithelial cell homeostasis.
Journal ArticleDOI
Blockade of individual Notch ligands and receptors controls graft-versus-host disease
Ivy T. Tran,Ashley R. Sandy,Alexis J. Carulli,Christen L. Ebens,Jooho Chung,Gloria T. Shan,Vedran Radojcic,Ann Friedman,Thomas Gridley,Amy L. Shelton,Pavan Reddy,Linda C. Samuelson,Minhong Yan,Christian W. Siebel,Ivan Maillard +14 more
TL;DR: It is demonstrated that notch1/Notch2 receptors and the Notch ligands Delta-like1/4 mediate all the effects of Notch signaling in T cells during GVHD, with dominant roles for Notch1 and Delta- like4.
Journal ArticleDOI
Notch receptor regulation of intestinal stem cell homeostasis and crypt regeneration
Alexis J. Carulli,Theresa M. Keeley,Elise S. Demitrack,Jooho Chung,Ivan Maillard,Linda C. Samuelson +5 more
TL;DR: Notch1 is the primary receptor regulating intestinal stem cell function and that Notch1 and Notch2 together regulate epithelial cell proliferation, cell fate determination, and post-injury regeneration, suggesting that higher Notch activity is required post- injury.
Journal ArticleDOI
Unraveling intestinal stem cell behavior with models of crypt dynamics
TL;DR: This review discusses the current advances and controversies of ISC biology as well as theoretical compartmental models that have been coupled with in vivo experimentation to investigate the mechanisms ofISC dynamics during homeostasis, tumorigenesis, repair and development.
Journal ArticleDOI
Notch signaling regulates gastric antral LGR5 stem cell function
Elise S. Demitrack,Gail B. Gifford,Theresa M. Keeley,Alexis J. Carulli,Kelli L. VanDussen,Dafydd G. Thomas,Thomas J. Giordano,Zhenyi Liu,Raphael Kopan,Linda C. Samuelson +9 more
TL;DR: It is reported that Notch signaling is essential for homeostasis of LGR5+ antral stem cells and aberrant activation of Notch in gastric stem cells may contribute to gastric tumorigenesis.