Amy L. Shelton

TL;DR: The view that increased hippocampal activation in aMCI is a dysfunctional condition and that targeting excess hippocampal activity has therapeutic potential is supported.

TL;DR: The studies emphasize the value of paralogue-specific antagonists in dissecting the contributions of distinct Notch receptors to differentiation and disease and reveal the therapeutic promise in targeting Notch1 and Notch2 independently.

TL;DR: It is proposed that learning and remembering the spatial structure of the surrounding environment involves interpreting the layout in terms of a spatial reference system imposed on the environment but defined by egocentric experience.

TL;DR: Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.

TL;DR: This paper found that mental representations of large spaces were viewpoint dependent, and that two views of a spatial layout appeared to produce two viewpoint-dependent representations in memory and that imagined headings aligned with the study views were more accessible than were novel headings in terms of both speed and accuracy of pointing judgments.