Alfred H. Schinkel

TL;DR: The findings explain some of the side effects in patients treated with a combination of carcinostatics and P-glycoprotein inhibitors and indicate that these inhibitors might be useful in selectively enhancing the access of a range of drugs to the brain.

TL;DR: This work aims to provide an overview of properties of the mammalian ABC transporters known to mediate significant transport of clinically relevant drugs.

TL;DR: Given the variety of drugs affected by P-glycoprotein transport, it may be of tremendous therapeutic value to apply insights to the development of drugs that should have either very poor or very good brain penetration, whichever is preferred for pharmacotherapeutic purposes.

TL;DR: After stable transfection of epithelial LLC-PK1 cells, MDR1 and MDR3 Pgp were localized in the apical membrane and newly synthesized short-chain analogs of various membrane lipids were recovered in theApical albumin-containing medium of MDR 1 cells but not control cells.

TL;DR: The results indicate that humans or animals with low or absent BCRP activity may be at increased risk for developing protoporphyria and diet-dependent phototoxicity and provide a striking illustration of the importance of drug transporters in protection from toxicity of normal food constituents.