MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine
Ardy van Helvoort,Alexander J. Smith,Hein Sprong,Ingo Fritzsche,Alfred H. Schinkel,Piet Borst,Gerrit van Meer +6 more
Reads0
Chats0
TLDR
After stable transfection of epithelial LLC-PK1 cells, MDR1 and MDR3 Pgp were localized in the apical membrane and newly synthesized short-chain analogs of various membrane lipids were recovered in theApical albumin-containing medium of MDR 1 cells but not control cells.About:
This article is published in Cell.The article was published on 1996-11-01 and is currently open access. It has received 853 citations till now. The article focuses on the topics: Apical membrane & Membrane lipids.read more
Citations
More filters
Journal ArticleDOI
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI
Targeting multidrug resistance in cancer
Gergely Szakács,Jill K. Paterson,Joseph A. Ludwig,Catherine Booth-Genthe,Michael M. Gottesman +4 more
TL;DR: Various approaches to combating multidrug-resistant cancer are described, including the development of drugs that engage, evade or exploit efflux by ABC transporters.
Journal ArticleDOI
The human ATP-binding cassette (ABC) transporter superfamily
TL;DR: The ATP-binding cassette (ABC) transporters are essential for many processes in the cell and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response.
Journal ArticleDOI
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
Suresh V. Ambudkar,Saibal Dey,Christine A. Hrycyna,Murali Ramachandra,Ira Pastan,Michael M. Gottesman +5 more
TL;DR: This review summarizes current research on the structure-function analysis of P-glycoprotein, its mechanism of action, and facts and speculations about its normal physiological role.
Biochemical, cellular, and pharmacological aspects of the multidrug
Suresh V. Ambudkar,Saibal Dey,Christine A. Hrycyna,Murali Ramachandra,Ira Pastan,Michael M. Gottesman +5 more
TL;DR: In this paper, a review summarizes current research on the structure-function analysis of P-glycoprotein, its mechanism of action, and facts and speculations about its normal physiological role.
References
More filters
Journal ArticleDOI
ABC Transporters: From Microorganisms to Man
TL;DR: This chapter discusses thebuilding blocks of the Transmembrane Complex, and some of the properties of these blocks have changed since the publication of the original manuscript in 1993.
Journal ArticleDOI
Biochemistry of multidrug resistance mediated by the multidrug transporter.
Michael M. Gottesman,Ira Pastan +1 more
Journal ArticleDOI
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
Alfred H. Schinkel,J. J. M. Smit,O. van Tellingen,Jos H. Beijnen,Els Wagenaar,L. Van Deemter,C. A. A. M. Mol,M. A. Van Der Valk,E. Robanus-Maandag,H te Riele,Anton Berns,Piet Borst +11 more
TL;DR: The findings explain some of the side effects in patients treated with a combination of carcinostatics and P-glycoprotein inhibitors and indicate that these inhibitors might be useful in selectively enhancing the access of a range of drugs to the brain.
Journal ArticleDOI
Brefeldin A: insights into the control of membrane traffic and organelle structure.
TL;DR: The relationship between the control of membrane traffic and the maintenance of organelle structure has been investigated with the use of a remarkable drug, brefeldin A (BFA), and some speculative models concerning the mechanism and regulation ofmembrane traffic within the central vacuolar system are proposed.
Journal ArticleDOI
Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
J. J. M. Smit,A.H. Schinkel,R.P.J. Oude Elferink,A.K. Groen,Els Wagenaar,L. Van Deemter,C. A. A. M. Mol,Roel Ottenhoff,N. M. T. Van Der Lugt,M van Roon,M. A. Van Der Valk,G.J.A. Offerhaus,A Berns,Piet Borst +13 more
TL;DR: It is concluded that the mdr2 P-glycoprotein has an essential role in the secretion of phosphatidylcholine into bile and hypothesize that it may be a phospholipid transport protein or phospholIPid flippase.
Related Papers (5)
Biochemistry of multidrug resistance mediated by the multidrug transporter.
Michael M. Gottesman,Ira Pastan +1 more