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Ali A. Aghdassi
Researcher at Greifswald University Hospital
Publications - 99
Citations - 3498
Ali A. Aghdassi is an academic researcher from Greifswald University Hospital. The author has contributed to research in topics: Pancreatitis & Acute pancreatitis. The author has an hindex of 25, co-authored 80 publications receiving 2635 citations. Previous affiliations of Ali A. Aghdassi include University of Minnesota & University of Greifswald.
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Journal ArticleDOI
European evidence-based guidelines on pancreatic cystic neoplasms
Marco Del Chiaro,Marc G. Besselink,Lianne Scholten,Marco J. Bruno,Djuna L. Cahen,Thomas M. Gress,Jeanin E. van Hooft,Markus M. Lerch,Julia Mayerle,Thilo Hackert,Sohei Satoi,Alessandro Zerbi,David Cunningham,Claudio De Angelis,Marc Giovanni,Enrique de-Madaria,Péter Hegyi,Jonas Rosendahl,Helmut Friess,Riccardo Manfredi,Philippe Lévy,Francisco X. Real,Alain Sauvanet,Mohammed Abu Hilal,Giovanni Marchegiani,Irene Esposito,Paula Ghaneh,Marc R. W. Engelbrecht,Paul Fockens,Nadine C.M. van Huijgevoort,Christopher L. Wolfgang,Claudio Bassi,Natalya Gubergrits,Caroline S. Verbeke,Günter Klöppel,Aldo Scarpa,Giuseppe Zamboni,Anne Marie Lennon,Malin Sund,Nikolaos Kartalis,Lars Grenacher,Massimo Falconi,Urban Arnelo,Kostantin V. Kopchak,Kofi Oppong,Colin J. McKay,Truls Hauge,Kevin C. Conlon,Mustapha Adham,Güralp O. Ceyhan,Roberto Salvia,Christos Dervenis,Peter J. Allen,François Paye,Detlef K. Bartsch,Matthias Löhr,Massimiliano Mutignani,Johanna Laukkarinen,Richard D. Schulick,Roberto Valente,Thomas Seufferlein,Gabriele Capurso,Ajith K. Siriwardena,John P. Neoptolemos,Aldis Pukitis,Ralf Segersvärd,Ali A. Aghdassi,Stefano Andrianello,Peter Bossuyt,Robin Bülow,Karina Cárdenas-Jaén,P. Cortegoso,Martina Fontana,Lena Haeberle,M. Heckler,Andrey Litvin,Kulbir Mann,Christoph W. Michalski,Patrick Michl,Gennaro Nappo,Giampaolo Perri,S. Persson,F. Scheufele,Francesco Sclafani,Manuel Schmidt,L. Venezia,F. Volker,M-P Vullierm,L. Wusten +88 more
TL;DR: A conservative approach is recommended for asymptomatic MCN and IPMN, and Lifelong follow-up of IPMN is recommended in patients who are fit for surgery.
Journal ArticleDOI
Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer.
Frank Ulrich Weiss,Ines J. Marques,Joost M. Woltering,Danielle H. Vlecken,Ali A. Aghdassi,Lars Ivo Partecke,Claus Dieter Heidecke,Markus M. Lerch,Christoph P. Bagowski +8 more
TL;DR: It is suggested that miR-10a is a key mediator of metastatic behavior in pancreatic cancer, which regulates metastasis via suppression of HOXB1 andHOXB3.
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Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma.
Ali A. Aghdassi,Phoebe A. Phillips,Vikas Dudeja,D. Dhaulakhandi,R. Sharif,Rajinder K. Dawra,Markus M. Lerch,Ashok K. Saluja +7 more
TL;DR: It is indicated that Hsp70 plays an important role in apoptosis and that selective HSp70 knockdown can be used to induce apoptosis in pancreatic cancer cells.
Journal ArticleDOI
Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer
Ali A. Aghdassi,Matthias Sendler,Annett Guenther,Julia Mayerle,CO Behn,Claus Dieter Heidecke,Helmut Friess,Markus W. Büchler,Matthias Evert,Markus M. Lerch,Frank Ulrich Weiss +10 more
TL;DR: An important role for histone deacetylation in the downregulation of E-cadherin in human pancreatic cancer is implied and inhibition of HDACs may be a promising antitumour therapy for Pancreatic cancer.
Journal ArticleDOI
Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice
Matthias Sendler,A. Dummer,Frank Ulrich Weiss,Burkhard Krüger,Thomas Wartmann,Karin Scharffetter-Kochanek,Nico van Rooijen,Sudarshan R. Malla,Ali A. Aghdassi,Walter Halangk,Markus M. Lerch,Julia Mayerle +11 more
TL;DR: The soluble inflammatory cell mediator TNFα directly induces premature protease activation and necrosis in pancreatic acinar cells and is suggested to be an effective treatment strategy that directly addresses the cellular causes of pancreatitis.