A
Ali A. Ashkar
Researcher at McMaster University
Publications - 152
Citations - 8816
Ali A. Ashkar is an academic researcher from McMaster University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 46, co-authored 145 publications receiving 7545 citations. Previous affiliations of Ali A. Ashkar include McMaster-Carr & Pasteur Institute.
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Journal ArticleDOI
Interferon γ Contributes to Initiation of Uterine Vascular Modification, Decidual Integrity, and Uterine Natural Killer Cell Maturation during Normal Murine Pregnancy
TL;DR: In vivo findings strongly suggest that uNK cell–derived IFN-γ modifies the expression of genes in the uterine vasculature and stroma, which initiates vessel instability and facilitates pregnancy-induced remodeling of decidual arteries.
Journal ArticleDOI
The Dual Nature of Type I and Type II Interferons
Amanda J. Lee,Ali A. Ashkar +1 more
TL;DR: Evidence is presented that both antiviral and immunomodulatory functions are critical during virus infection to not only limit virus replication and initiate an appropriate antiviral immune response, but to also negatively regulate this response to minimize tissue damage.
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Progesterone Increases Susceptibility and Decreases Immune Responses to Genital Herpes Infection
TL;DR: It is shown that Depo-provera treatment changes susceptibility and local immune responses to genital HSV-2 infection and mice given progesterone and immunized at diestrus or estrus were completely protected from intravaginal challenge.
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Interferon Gamma in Successful Pregnancies
TL;DR: The dynamic roles of IFNG in successful pregnancy is described and data onIFNG in gestational pathologies is summarized.
Journal ArticleDOI
Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy.
TL;DR: It is indicated that uNK cell development and maturation share some aspects with NK cell development in other tissues, but also display distinctive tissue-specific regulation.