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Ali Tofigh
Researcher at McGill University
Publications - 13
Citations - 727
Ali Tofigh is an academic researcher from McGill University. The author has contributed to research in topics: Gene signature & Signal transduction. The author has an hindex of 9, co-authored 13 publications receiving 668 citations. Previous affiliations of Ali Tofigh include Royal Institute of Technology.
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Journal ArticleDOI
SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor.
TL;DR: IGF-1 promotes the modification of IGF-1R by small ubiquitin-like modifier protein–1 (SUMO-1) and its translocation to the nucleus, demonstrating a SUMOylation-mediated mechanism of IGF -1R signaling that has potential implications for gene regulation.
Journal ArticleDOI
Simultaneous Identification of Duplications and Lateral Gene Transfers
TL;DR: This paper describes a combinatorial model where so-called DTL-scenarios are used to explain the differences between a gene tree and a corresponding species tree taking into account gene duplications, gene losses, and lateral gene transfers (also known as horizontal gene transfers).
Journal ArticleDOI
A Bayesian method for analyzing lateral gene transfer.
Joel Sjöstrand,Joel Sjöstrand,Ali Tofigh,Vincent Daubin,Lars Arvestad,Lars Arvestad,Bengt Sennblad,Bengt Sennblad,Jens Lagergren,Jens Lagergren +9 more
TL;DR: A Bayesian Markov-chain Monte Carlo-based method is presented that integrates GD, gene loss, LGT, and sequence evolution, and is applied in a genome-wide analysis of two groups of bacteria: Mollicutes and Cyanobacteria.
Proceedings ArticleDOI
Simultaneous identification of duplications and lateral transfers
TL;DR: This paper introduces a combinatorial model that incorporates duplication events as well as lateral gene transfer events and gives an NP-completeness proof which suggests that the intractability is due to the demand that the dt-scenarios be acyclic.
Journal ArticleDOI
The Prognostic Ease and Difficulty of Invasive Breast Carcinoma
Ali Tofigh,Matthew Suderman,Eric Paquet,Julie Livingstone,Nicholas Bertos,Sadiq M. Saleh,Hong Zhao,Margarita Souleimanova,Sean Cory,Robert Lesurf,Solmaz Shahalizadeh,Norberto Garcia Lopez,Norberto Garcia Lopez,Yasser Riazalhosseini,Atilla Omeroglu,Atilla Omeroglu,Josie Ursini-Siegel,Morag Park,Vanessa Dumeaux,Michael Hallett +19 more
TL;DR: The approach constructively shows how to avoid confounding due to a patient's subtype, clinicopathological profile, or treatment profile and identifies patients who are predicted to have good outcome at time of diagnosis but who experience a distant metastasis within 5 years.