A
Alice E. van der Ende
Researcher at Vanderbilt University
Publications - 9
Citations - 481
Alice E. van der Ende is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Drug delivery & Polyester. The author has an hindex of 8, co-authored 9 publications receiving 449 citations.
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Journal ArticleDOI
Targeted Nanoparticles That Deliver a Sustained, Specific Release of Paclitaxel to Irradiated Tumors
Ralph J. Passarella,Daniel E. Spratt,Alice E. van der Ende,John G. Phillips,Hongmei Wu,Vasanth Sathiyakumar,Li Zhou,Dennis E. Hallahan,Eva Harth,Roberto Diaz +9 more
TL;DR: This targeting agent combines a novel recombinant peptide with a paclitaxel-encapsulating nanoparticle that specifically targets irradiated tumors, increasing apoptosis and tumor growth delay in a manner superior to known chemotherapy approaches.
Journal ArticleDOI
Approach to Formation of Multifunctional Polyester Particles in Controlled Nanoscopic Dimensions
TL;DR: The development of a novel methodology to prepare functionalized well-defined 3-D nanoparticle polyester materials in targeted nanoscopic ranges with amorphous morphologies or tailored crystallinities that offer a multitude of utilizations as a result of their unique properties and control in preparation is described.
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Tailored polyester nanoparticles: post-modification with dendritic transporter and targeting units via reductive amination and thiol-ene chemistry
TL;DR: Several efficient post-modification strategies to accommodate the demands of biomaterials for mild conjugation chemistries utilizing amine and thiol units to form polyester bioconjugates with specific functionalities as a platform for an array of therapeutic applications are described.
Journal ArticleDOI
``Click'' Reactions: Novel Chemistries for Forming Well-defined Polyester Nanoparticles
Alice E. van der Ende,Jameson Harrell,Vasanth Sathiyakumar,Mika E. Meschievitz,Jared Katz,Karen Adcock,Eva Harth +6 more
TL;DR: In this article, the synthesis of discrete functionalized polyester nanoparticles in selected nanoscale size dimensions via a controlled intermolecular chain cross-linking process facilitated via "click"-chemistry approaches such as the Cu(I)-catalyzed 1,3-dipolar cycloaddition of azides and thiol−ene reactions is presented.
Journal ArticleDOI
Sequential targeted delivery of paclitaxel and camptothecin using a cross-linked "nanosponge" network for lung cancer chemotherapy.
Ghazal Hariri,Aaron D. Edwards,Tyler B. Merrill,Joshua M. Greenbaum,Alice E. van der Ende,Eva Harth +5 more
TL;DR: The efficacy of the NP delivery system in sequential treatments was corroborated in both in vitro and in vivo lung cancer models showing increased G2/M phase arrest and microtubule disruption, resulting in enhanced apoptotic cell death, decreased cell proliferation and vascular density.