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Alice Fletcher-Etherington
Researcher at University of Cambridge
Publications - 7
Citations - 111
Alice Fletcher-Etherington is an academic researcher from University of Cambridge. The author has contributed to research in topics: Human cytomegalovirus & Immune system. The author has an hindex of 2, co-authored 5 publications receiving 71 citations.
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Journal ArticleDOI
High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms.
Katie Nightingale,Kai-Min Lin,Benjamin J. Ravenhill,Colin Davies,Luis Nobre,Ceri Alan Fielding,Eva Ruckova,Alice Fletcher-Etherington,Lior Soday,Hester Nichols,Daniel Sugrue,Edward Chung Yern Wang,Pablo Moreno,Yagnesh Umrania,Edward L. Huttlin,Robin Antrobus,Andrew J. Davison,Gavin William Grahame Wilkinson,Richard J. Stanton,Peter Tomasec,Michael P. Weekes +20 more
TL;DR: A multiplexed approach to discover proteins with innate immune function on the basis of active degradation by the proteasome or lysosome during early-phase HCMV infection revealed that helicase-like transcription factor (HLTF), a DNA helicase important in DNA repair, potently inhibits early viral gene expression but is rapidly degraded during infection.
Journal ArticleDOI
Human cytomegalovirus protein pUL36: A dual cell death pathway inhibitor
Alice Fletcher-Etherington,Luis Nobre,Katie Nightingale,Robin Antrobus,Jenna Nichols,Andrew J. Davison,Richard J. Stanton,Michael P. Weekes +7 more
TL;DR: A proteomic screen to identify human proteins targeted for destruction by HCMV found that the key necroptosis mediator MLKL is degraded throughout infection, finding that pUL36 is a dual cell death pathway inhibitor, and may represent an important therapeutic target.
Journal ArticleDOI
Selective modulation of cell surface proteins during vaccinia infection: A resource for identifying viral immune evasion strategies
Delphine Depierreux,Arwen F. Altenburg,Lior Soday,Alice Fletcher-Etherington,Robin Anthrobus,Brian J. Ferguson,Michael P. Weekes,Geoffrey Smith +7 more
TL;DR: Collectively, this dataset constitutes a valuable resource for future studies on antiviral immunity, host-pathogen interaction, poxvirus biology, vector-based vaccine design and oncolytic therapy.
Posted ContentDOI
Human cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex
Katie Nightingale,Ceri Alan Fielding,Zerbe C,Leah M. Hunter,Martin Potts,Alice Fletcher-Etherington,Luis Nobre,Edward Chung Yern Wang,Blair L. Strang,Jack W. Houghton,Robin Antrobus,Nicolás M. Suárez,Jenna Nichols,Andrew J. Davison,Richard J. Stanton,Michael P. Weekes +15 more
TL;DR: In this article, the authors employed two orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins downregulated by viral factors expressed during the latest phases of viral infection.
Posted ContentDOI
Human cytomegalovirus protein pUL36: a dual cell death pathway inhibitor
Alice Fletcher-Etherington,Luis Nobre,Katie Nightingale,Robin Antrobus,Jenna Nichols,Andrew J. Davison,Richard J. Stanton,Michael P. Weekes +7 more
TL;DR: A proteomic screen is used to identify human proteins targeted for destruction by HCMV, finding that the key necroptosis mediator MLKL is degraded throughout infection and pUL36 is a dual cell death pathway inhibitor.