P
Peter Tomasec
Researcher at Cardiff University
Publications - 47
Citations - 4137
Peter Tomasec is an academic researcher from Cardiff University. The author has contributed to research in topics: Human cytomegalovirus & MHC class I. The author has an hindex of 28, co-authored 45 publications receiving 3745 citations. Previous affiliations of Peter Tomasec include University of Wales.
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Journal ArticleDOI
Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40
Peter Tomasec,Veronique M. Braud,Carole R. Rickards,Martin B. Powell,Brian P. McSharry,Stephan D. Gadola,Vincenzo Cerundolo,Leszek K. Borysiewicz,Andrew J. McMichael,Gavin William Grahame Wilkinson +9 more
TL;DR: It is shown that, independently of the transporter associated with antigen processing, gpUL40 can up-regulate expression of HLA-E, which protects targets from NK cell lysis, which is up-regulated by HCMV.
Journal ArticleDOI
Quantitative temporal viromics: an approach to investigate host-pathogen interaction.
Michael P. Weekes,Michael P. Weekes,Peter Tomasec,Edward L. Huttlin,Ceri Alan Fielding,David P. Nusinow,Richard J. Stanton,Edward Chung Yern Wang,Rebecca Aicheler,Isa Murrell,Gavin William Grahame Wilkinson,Paul J. Lehner,Steven P. Gygi +12 more
TL;DR: A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction, applicable to any virus with a robust in vitro model.
Journal ArticleDOI
Downregulation of natural killer cell–activating ligand CD155 by human cytomegalovirus UL141
Peter Tomasec,Edward Chung Yern Wang,Andrew J. Davison,Borivoj Vojtesek,Melanie Armstrong,Cora Griffin,Brian P. McSharry,Rebecca J. Morris,Sian Llewellyn-Lacey,Carole R. Rickards,Akio Nomoto,Christian Sinzger,Gavin William Grahame Wilkinson +12 more
TL;DR: It is shown that the viral UL141 gene product has an immunomodulatory function that is associated with low-passage strains of human cytomegalovirus.
Journal ArticleDOI
Modulation of natural killer cells by human cytomegalovirus
Gavin William Grahame Wilkinson,Peter Tomasec,Richard J. Stanton,Melanie Armstrong,Virginie Prod'homme,Rebecca Aicheler,Brian P. McSharry,Carole R. Rickards,Daniel Cochrane,Sian Llewellyn-Lacey,Edward Chung Yern Wang,Cora Griffin,Andrew J. Davison +12 more
TL;DR: The mechanisms by which HCMV systematically evades (or, more properly, modulates) NK cell recognition constitutes an area of growing understanding that is enhancing the authors' appreciation of the basic mechanisms of NK cell function in humans.
Journal ArticleDOI
Reconstruction of the complete human cytomegalovirus genome in a BAC reveals RL13 to be a potent inhibitor of replication
Richard J. Stanton,Katarina Baluchova,Derrick J. Dargan,Charles Cunningham,Orla Sheehy,Sepehr Seirafian,Brian P. McSharry,M. Lynne Neale,James A. Davies,Peter Tomasec,Andrew J. Davison,Gavin William Grahame Wilkinson +11 more
TL;DR: To overcome rapid emergence of mutations in genetically intact HCMV, a system in which RL13 and UL131A were conditionally repressed during virus propagation is developed, which permits studies to be undertaken with a clonal, characterized H CMV strain containing the complete wild-type gene complement.