C
Ceri Alan Fielding
Researcher at Cardiff University
Publications - 54
Citations - 3781
Ceri Alan Fielding is an academic researcher from Cardiff University. The author has contributed to research in topics: Human cytomegalovirus & Receptor. The author has an hindex of 28, co-authored 47 publications receiving 3277 citations. Previous affiliations of Ceri Alan Fielding include Novartis & University of Wales.
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Journal ArticleDOI
Quantitative temporal viromics: an approach to investigate host-pathogen interaction.
Michael P. Weekes,Michael P. Weekes,Peter Tomasec,Edward L. Huttlin,Ceri Alan Fielding,David P. Nusinow,Richard J. Stanton,Edward Chung Yern Wang,Rebecca Aicheler,Isa Murrell,Gavin William Grahame Wilkinson,Paul J. Lehner,Steven P. Gygi +12 more
TL;DR: A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction, applicable to any virus with a robust in vitro model.
Journal ArticleDOI
IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.
Ceri Alan Fielding,Rachel M. McLoughlin,Louise McLeod,Chantal Sophie Colmont,Meri Najdovska,Dianne Grail,Matthias Ernst,Simon Arnett Jones,Nicholas Topley,Brendan J. Jenkins +9 more
TL;DR: It is genetically defined that IL-6-driven signaling via STAT3, but not STAT1, limits the inflammatory recruitment of neutrophils, and therefore represents a critical event for the termination of the innate immune response.
Journal ArticleDOI
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
Rachel M. McLoughlin,Brendan J. Jenkins,Dianne Grail,Anwen Sian Williams,Ceri Alan Fielding,Clare R. Parker,Matthias Ernst,Nicholas Topley,Simon Arnett Jones +8 more
TL;DR: It is reported that IL-6 selectively governs T cell infiltration by regulatingChemokine secretion and chemokine receptor expression on the CD3+ infiltrate and STAT3 plays a defining role in IL- 6-mediated T cell migration.
Journal ArticleDOI
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
Athena Chalaris,Björn Rabe,Krzysztof Paliga,Hans Lange,Tamas Laskay,Ceri Alan Fielding,Simon Arnett Jones,Stefan Rose-John,Jürgen Scheller +8 more
TL;DR: It is demonstrated that IL6R is shed from apoptotic human neutrophils, which is relevant to the control of acute inflammation, where transition from the initial neutrophil infiltration to a more sustained population of mononuclear cells is essential for the resolution of the inflammatory process.
Journal ArticleDOI
Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation
Ceri Alan Fielding,Gareth W. Jones,Rachel M. McLoughlin,Louise McLeod,Victoria Jayne Hammond,Javier Uceda,Anwen Sian Williams,Mark Lambie,Thomas L. Foster,Chia-Te Liao,Christopher M. Rice,Claire J. Greenhill,Chantal Sophie Colmont,Emily Hams,Barbara Coles,Ann Kift-Morgan,Zarabeth Newton,Katherine J. Craig,John D. Williams,Geraint T. Williams,Simon J. Davies,Ian R. Humphreys,Valerie B. O'Donnell,Philip R. Taylor,Brendan J. Jenkins,Nicholas Topley,Simon Arnett Jones +26 more
TL;DR: Fibrosis is observed in mice lacking interferon-γ (IFN-γ), STAT1, or RAG-1 and IL-6 causes compromised tissue repair by shifting acute inflammation into a more chronic profibrotic state through induction of Th1 cell responses as a consequence of recurrent inflammation.