A
Alice H. Cavanaugh
Researcher at National Institutes of Health
Publications - 29
Citations - 1998
Alice H. Cavanaugh is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transcription (biology) & RNA polymerase II. The author has an hindex of 22, co-authored 29 publications receiving 1917 citations. Previous affiliations of Alice H. Cavanaugh include Sewanee: The University of the South & Pennsylvania State University.
Papers
More filters
Journal ArticleDOI
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
Katherine M. Hannan,Yves Brandenburger,Anna Jenkins,Kerith Sharkey,Alice H. Cavanaugh,Lawrence I. Rothblum,Tom Moss,Gretchen Poortinga,Grant A. McArthur,Richard B. Pearson,Richard B. Pearson,Ross D. Hannan,Ross D. Hannan +12 more
TL;DR: It is shown that mTOR is required for the rapid and sustained serum-induced activation of 45S ribosomal gene transcription (rDNA transcription), a major rate-limiting step in ribosome biogenesis and cellular growth.
Journal ArticleDOI
Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product
Alice H. Cavanaugh,William M. Hempel,Laura Taylor,Vitaly Rogalsky,German Todorov,Lawrence I. Rothblum +5 more
TL;DR: It is reported that there is an accumulation of Rb protein in the nucleoli of differentiated U937 cells which correlates with inhibition of rDNA transcription, and that Rb directly represses transcription of the rRNA genes.
Journal ArticleDOI
Arsenite and cadmium(II) as probes of glucocorticoid receptor structure and function.
TL;DR: The results confirm directly the earlier hypothesis that steroid binding to rat glucocorticoid receptors involves a vicinal dithiol and show that arsenite is a potent new reagent for probing receptor structure and function.
Journal ArticleDOI
Agonist-Driven Maturation and Plasma Membrane Insertion of Calcium-Sensing Receptors Dynamically Control Signal Amplitude
TL;DR: Multiwavelength total internal reflection fluorescence microscopy is used to demonstrate that the signaling properties of the CaSR result from agonist-driven maturation and insertion of CaSRs into the plasma membrane, representing a previously unknown mechanism of regulation that may be relevant to other receptors that operate in the chronic presence of agonist.
Journal ArticleDOI
RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest.
Katherine M. Hannan,Brian K. Kennedy,Alice H. Cavanaugh,Ross D. Hannan,Iwona Hirschler-Laszkiewicz,Leonard S. Jefferson,Lawrence I. Rothblum +6 more
TL;DR: A model wherein regulation of the binding of UBF to Rb and, perhaps the cellular content of PAF53, are components of the mechanism through which cell cycle and rDNA transcription are linked is presented.