K
Katherine M. Hannan
Researcher at Australian National University
Publications - 85
Citations - 4768
Katherine M. Hannan is an academic researcher from Australian National University. The author has contributed to research in topics: Ribosome biogenesis & RNA polymerase I. The author has an hindex of 34, co-authored 80 publications receiving 4104 citations. Previous affiliations of Katherine M. Hannan include The Heart Research Institute & Alfred Hospital.
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Journal ArticleDOI
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.
Katherine M. Hannan,Yves Brandenburger,Anna Jenkins,Kerith Sharkey,Alice H. Cavanaugh,Lawrence I. Rothblum,Tom Moss,Gretchen Poortinga,Grant A. McArthur,Richard B. Pearson,Richard B. Pearson,Ross D. Hannan,Ross D. Hannan +12 more
TL;DR: It is shown that mTOR is required for the rapid and sustained serum-induced activation of 45S ribosomal gene transcription (rDNA transcription), a major rate-limiting step in ribosome biogenesis and cellular growth.
Journal ArticleDOI
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function.
Katarzyna Jastrzebski,Katherine M. Hannan,Elissaveta B Tchoubrieva,Ross D. Hannan,Richard B. Pearson +4 more
TL;DR: The current models for mTOR dependent regulation of ribosome function and biogenesis as well as its role in coordinating growth factor and nutrient signaling to facilitate homeostasis of cell growth and proliferation are reviewed.
Journal ArticleDOI
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer.
Joanna C. Chan,Katherine M. Hannan,Kim Riddell,Pui Yee Ng,Abigail Peck,Rachel S. Lee,Sandy S.C. Hung,Megan Victoria Astle,Megan J. Bywater,Meaghan Wall,Meaghan Wall,Meaghan Wall,Gretchen Poortinga,Gretchen Poortinga,Katarzyna Jastrzebski,Karen E. Sheppard,Brian A. Hemmings,Michael N. Hall,Ricky W. Johnstone,Grant A. McArthur,Grant A. McArthur,Grant A. McArthur,Ross D. Hannan,Ross D. Hannan,Ross D. Hannan,Richard B. Pearson +25 more
TL;DR: It is shown that the kinase AKT regulates ribosome biogenesis at multiple levels to promote ribosomal RNA (rRNA) synthesis and is likely to be a fundamental component of the therapeutic response to AKT inhibitors in cancer.
Journal ArticleDOI
Targeting the nucleolus for cancer intervention
Jaclyn E Quin,Jaclyn E Quin,Jennifer R. Devlin,Jennifer R. Devlin,Donald P. Cameron,Katherine M. Hannan,Katherine M. Hannan,Richard B. Pearson,Ross D. Hannan +8 more
TL;DR: Extra-ribosomal functions of the nucleolus position it as a central integrator of cellular proliferation and stress signaling, and are emerging as important mechanisms for modulating how oncogenes and tumor suppressors operate in normal and malignant cells.
Journal ArticleDOI
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
Megan Victoria Astle,Katherine M. Hannan,Puiyee Ng,Rachel S. Lee,Amee J George,Amee J George,Amee J George,Andy K Hsu,Ygal Haupt,Ygal Haupt,Ross D. Hannan,Ross D. Hannan,Ross D. Hannan,Richard B. Pearson,Richard B. Pearson,Richard B. Pearson +15 more
TL;DR: The demonstration that mTORC1 is an essential mediator of AKT-induced senescence raises the possibility that targeting m TORC1 in tumours with activated PI3K/AKT signalling may exert unexpected detrimental effects due to inactivation of a senescences brake on potential cancer-initiating cells.