Yves Brandenburger

TL;DR: It is shown that mTOR is required for the rapid and sustained serum-induced activation of 45S ribosomal gene transcription (rDNA transcription), a major rate-limiting step in ribosome biogenesis and cellular growth.

TL;DR: It is shown that granulocytic cells deficient in the c‐MYC antagonist MAD1 display increased cell volume, rDNA transcription and protein synthesis, providing a mechanism for coordination of ribosome biogenesis and cell growth under conditions of sustained growth inhibition such as granulocyte differentiation.

TL;DR: It is unequivocally demonstrated that Ang II can directly promote cardiac myocyte growth via AT1A receptors expressed on these cells and reveal for the first time the important contribution of EGF receptor–transactivated MAPK signaling to this process.

TL;DR: Left ventricular hypertrophy is an adaptive response to sustained increases in blood pressure and hormone imbalances and is associated with programmed responses at the molecular and biochemical level in different subsets of cardiac cells, including the cardiac muscle cells, fibroblasts, conductive tissue and coronary vasculature.

TL;DR: It is demonstrated that the introduction of UBF antisense RNA into myocytes, using adenovirus approaches, efficiently inhibits UBF accumulation during induction of cardiomyocyte hypertrophy and implicate UBF as a major regulatory factor in this process.