A
Alison C. MacKinnon
Researcher at University of Edinburgh
Publications - 96
Citations - 6665
Alison C. MacKinnon is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Galectin-3 & Idiopathic pulmonary fibrosis. The author has an hindex of 35, co-authored 87 publications receiving 5734 citations.
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Journal ArticleDOI
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
Tariq Sethi,Robert C. Rintoul,Sarah M. Moore,Alison C. MacKinnon,Donald Salter,Chin Choo,Edwin R. Chilvers,Ian Dransfield,Seamas C. Donnelly,Robert M. Strieter,Christopher Haslett +10 more
TL;DR: It is shown here that SCLC is surrounded by an extensive stroma of extracellular matrix (ECM) at both primary and metastatic sites, which enhances tumorigenicity and confers resistance to chemotherapeutic agents as a result of β1 integrin-stimulated tyrosine kinase activation suppressing chemotherapy-induced apoptosis.
Journal ArticleDOI
Galectin-3 regulates myofibroblast activation and hepatic fibrosis
Neil C. Henderson,Alison C. MacKinnon,Sarah L. Farnworth,Françoise Poirier,Francesco Paolo Russo,John P. Iredale,Christopher Haslett,Kenneth J. Simpson,Tariq Sethi +8 more
TL;DR: In vivo siRNA knockdown of Galectin-3 inhibited myofibroblast activation after hepatic injury and may therefore provide an alternative therapeutic approach to the prevention and treatment of liver fibrosis.
Journal ArticleDOI
Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis.
Neil C. Henderson,Alison C. MacKinnon,Sarah L. Farnworth,Tiina Kipari,Christopher Haslett,John P. Iredale,Fu-Tong Liu,Jeremy Hughes,Tariq Sethi +8 more
TL;DR: It is demonstrated for the first time that galectin-3 expression and secretion by macrophages is a major mechanism linking macrophage to the promotion of renal fibrosis.
Journal ArticleDOI
Regulation of Alternative Macrophage Activation by Galectin-3
Alison C. MacKinnon,Sarah L. Farnworth,Philip S. Hodkinson,Neil C. Henderson,Kirsten M. Atkinson,Hakon Leffler,Ulf J. Nilsson,Christopher Haslett,Stuart J. Forbes,Tariq Sethi +9 more
TL;DR: In this paper, a siRNA-targeted deletion of the galectin-3 gene in 129 mice specifically restrains IL-4/IL-13-induced alternative macrophage activation in bone marrow-derived macrophages.
Journal ArticleDOI
Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3
Alison C. MacKinnon,Michael A Gibbons,Sarah L. Farnworth,Hakon Leffler,Ulf J. Nilsson,Tamara Delaine,A. John Simpson,A. John Simpson,Stuart J. Forbes,Nikhil Hirani,Jack Gauldie,Tariq Sethi +11 more
TL;DR: This study identifies galectin-3 as an important regulator of lung fibrosis and provides a proof of principle for galectine-3 inhibition as a potential novel therapeutic strategy for IPF.