S
Stuart J. Forbes
Researcher at University of Edinburgh
Publications - 225
Citations - 19272
Stuart J. Forbes is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Liver regeneration & Stem cell. The author has an hindex of 59, co-authored 212 publications receiving 16068 citations. Previous affiliations of Stuart J. Forbes include St Mary's Hospital & Medical Research Council.
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Journal ArticleDOI
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
Jeremy S. Duffield,Stuart J. Forbes,Christothea M. Constandinou,Spike Clay,Marina Partolina,Srilatha Vuthoori,Shengji Wu,Richard A. Lang,John P. Iredale +8 more
TL;DR: These data provide the first clear evidence that functionally distinct subpopulations of macrophages exist in the same tissue and that these macrophage play critical roles in both the injury and recovery phases of inflammatory scarring.
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Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)
Jesus M. Banales,Vincenzo Cardinale,Guido Carpino,Marco Marzioni,Jesper B. Andersen,Pietro Invernizzi,Guro Elisabeth Lind,Trine Folseraas,Stuart J. Forbes,Laura Fouassier,Andreas Geier,Diego F. Calvisi,Joachim C. Mertens,Michael Trauner,Antonio Benedetti,Luca Maroni,Javier Vaquero,Rocio I.R. Macias,Chiara Raggi,Maria J. Perugorria,Eugenio Gaudio,Kirsten Muri Boberg,Jose J.G. Marin,Domenico Alvaro +23 more
TL;DR: This Consensus Statement aims to provide valuable information on classifications, pathological features, risk factors, cells of origin, genetic and epigenetic modifications and current therapies available for this cancer.
Journal ArticleDOI
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis
Prakash Ramachandran,Antonella Pellicoro,Madeleine A. Vernon,Luke Boulter,Rebecca L. Aucott,Aysha Ali,Stephen N. Hartland,Victoria K. Snowdon,Andrea Cappon,Timothy T. Gordon-Walker,Mike J. Williams,Donald R. Dunbar,Jonathan R. Manning,Nico van Rooijen,Jonathan A. Fallowfield,Stuart J. Forbes,John P. Iredale +16 more
TL;DR: The restorative macrophage phenotype was recapitulated in vitro by the phagocytosis of cellular debris with associated activation of the ERK signaling cascade, offering a therapeutic strategy to this orphan pathological process.
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Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.
Luke Boulter,Olivier Govaere,Thomas G. Bird,Sorina Radulescu,Prakash Ramachandran,Antonella Pellicoro,Rachel A. Ridgway,Sang Soo Seo,Bart Spee,Nico Van Rooijen,Nico Van Rooijen,Owen J. Sansom,John P. Iredale,Sally Lowell,Tania Roskams,Stuart J. Forbes +15 more
TL;DR: It is found that during biliary regeneration, expression of Jagged 1 by myofibroblasts promoted Notch signaling in HPCs and thus their biliary specification to cholangiocytes and thus the promotion of their specification to hepatocytes.
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Bone marrow contributes to renal parenchymal turnover and regeneration
Richard Poulsom,Stuart J. Forbes,Kairbaan Hodivala-Dilke,Eoin Ryan,Susannah M. Wyles,Sobana Navaratnarasah,Rosemary Jeffery,Toby Hunt,Malcolm R. Alison,Terence Cook,Charles D. Pusey,Nicholas A. Wright +11 more
TL;DR: The presence of bone marrow‐derived cells was noted in both histologically normal mouse kidneys and in human transplanted kidneys suffering damage from a variety of causes, indicating that bone marrow cells contribute to both normal turnover of renal epithelia and regeneration after damage, and is suggested that this could be exploited therapeutically.