D
Donald Salter
Researcher at University of Edinburgh
Publications - 209
Citations - 12662
Donald Salter is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Chondrocyte & Mechanotransduction. The author has an hindex of 54, co-authored 204 publications receiving 11601 citations. Previous affiliations of Donald Salter include Queen's University & Edinburgh Cancer Research Centre.
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Journal ArticleDOI
Osteoarthritis cartilage histopathology: grading and staging
Kenneth P.H. Pritzker,Kenneth P.H. Pritzker,Sergio A. Jimenez,Keld Ostergaard,J.-P. Pelletier,P A Revell,Donald Salter,W.B. van den Berg +7 more
TL;DR: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply as discussed by the authors, however, further studies are required to confirm the system's utility, as well as their reproducibility and validity.
Journal ArticleDOI
18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial
Nikhil Joshi,Alex T. Vesey,Michelle C. Williams,Anoop S V Shah,Patrick A. Calvert,Felicity H. Craighead,Su Ern Yeoh,William Wallace,Donald Salter,Alison Fletcher,Edwin J R van Beek,Andrew D. Flapan,Neal G. Uren,Miles Behan,Nicholas L. Cruden,Nicholas L. Mills,Keith A.A. Fox,James H.F. Rudd,Marc R. Dweck,David E. Newby +19 more
TL;DR: 18)F-NaF PET-CT is the first non-invasive imaging method to identify and localise ruptured and high-risk coronary plaque and is needed to establish whether this method can improve the management and treatment of patients with coronary artery disease.
Journal ArticleDOI
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
Tariq Sethi,Robert C. Rintoul,Sarah M. Moore,Alison C. MacKinnon,Donald Salter,Chin Choo,Edwin R. Chilvers,Ian Dransfield,Seamas C. Donnelly,Robert M. Strieter,Christopher Haslett +10 more
TL;DR: It is shown here that SCLC is surrounded by an extensive stroma of extracellular matrix (ECM) at both primary and metastatic sites, which enhances tumorigenicity and confers resistance to chemotherapeutic agents as a result of β1 integrin-stimulated tyrosine kinase activation suppressing chemotherapy-induced apoptosis.
Journal ArticleDOI
Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study
Eleftheria Zeggini,Kalliope Panoutsopoulou,Lorraine Southam,Lorraine Southam,N W Rayner,Aaron G. Day-Williams,M C Lopes,M C Lopes,Vesna Boraska,Tõnu Esko,Evangelos Evangelou,A Hoffman,Jeanine J. Houwing-Duistermaat,Thorvaldur Ingvarsson,Ingileif Jonsdottir,Ingileif Jonsdottir,H Jonnson,Hanneke J. M. Kerkhof,Margreet Kloppenburg,Steffan D. Bos,Massimo Mangino,Sarah Metrustry,P E Slagboom,Gudmar Thorleifsson,Raine Eva.,Madhushika Ratnayake,Michelle Ricketts,C Beazley,Hannah Blackburn,Suzannah Bumpstead,K S Elliott,Sarah E. Hunt,Simon C. Potter,Shin S-Y.,Vijay K. Yadav,Guangju Zhai,K Sherburn,K Dixon,E Arden,N Aslam,Battley P-K.,I Carluke,Sally Doherty,Allan Gordon,J Joseph,Richard Keen,N Koller,Sheryl Mitchell,F O'Neill,E Paling,Mike R. Reed,Fernando Rivadeneira,D Swift,K Walker,Bridget Watkins,M. Wheeler,Fraser Birrell,Ioannidis Jpa.,Ingrid Meulenbelt,Andres Metspalu,Ashok Rai,Donald Salter,K. Stefansson,U Stykarsdottir,A.G. Uitterlinden,van Meurs Jbj.,Karen E. Chapman,Panagiotis Deloukas,Ollier Wer.,Gillian A. Wallis,Nigel K Arden,Andrew Carr,Michael Doherty,Andrew McCaskie,J M Willkinson,Stuart Ralston,Ana M. Valdes,Tim D. Spector,John Loughlin +78 more
TL;DR: One of the signals close to genome-wide significance was within the FTO gene, which is involved in regulation of bodyweight—a strong risk factor for osteoarthritis.
Journal Article
Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene
Colin A. Purdie,David J. Harrison,Audrey Peter,L Dobbie,White S,Sarah E. M. Howie,Donald Salter,Colin C. Bird,Andrew H. Wyllie,Martin L. Hooper +9 more
TL;DR: A large deletion within the p53 gene is generated, consistent with the concept that p53 acts as a tumour suppressor by preventing the propagation of DNA damage to daughter cells.