Alison Leed

TL;DR: Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.

TL;DR: The findings support the further development of PrP-lowering ASOs and of CSF PrP as a pharmacodynamic biomarker and salt dependence of the affinity measured by isothermal titration calorimetry are supported.

TL;DR: In the ligand-independent crystal form, this MBP-MCL1 construct dramatically improves the structural understanding of well-validated MCL1 ligands, and will likely catalyze the structure-based optimization of high affinity M CL1 inhibitors.

TL;DR: A direct binding screen of 100 000 sp(3)-rich molecules identified a single diastereomer of a macrolactam core that binds specifically to myeloid cell leukemia 1 (MCL1).

TL;DR: The exceptionally low hit rate observed here suggests that PrP is a difficult target for small-molecule binders, whereas orthogonal binder discovery methods could yield high-affinity compounds, non-small-Molecule modalities may offer independent paths forward against prion disease.