A
Alison S. Walker
Researcher at King's College London
Publications - 8
Citations - 715
Alison S. Walker is an academic researcher from King's College London. The author has contributed to research in topics: GCaMP & Visual system. The author has an hindex of 7, co-authored 8 publications receiving 618 citations. Previous affiliations of Alison S. Walker include Helen Wills Neuroscience Institute.
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Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
TL;DR: Evidence of potent activation of α7 nAChRs via an allosteric transmembrane site is presented and a compound with close chemical similarity to TQS (4BP-TQS) is found to be a potentAllosteric agonist of α 7 nA ChRs.
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A Photostable Silicon Rhodamine Platform for Optical Voltage Sensing
TL;DR: The design and synthesis of a photostable, far-red to near-infrared (NIR) platform for optical voltage sensing and its high speed, sensitivity, photostability and long-wavelength fluorescence profiles make it a useful platform for the noninvasive, optical dissection of neuronal activity.
Journal ArticleDOI
Parametric functional maps of visual inputs to the tectum.
Nikolas Nikolaou,Andrew S. Lowe,Alison S. Walker,Fatima Abbas,Paul R. Hunter,Ian D. Thompson,Martin P. Meyer +6 more
TL;DR: A genetically encoded reporter of presynaptic function (SyGCaMP3) is used to record visually evoked activity in the population of RGC axons innervating the zebrafish tectum, providing a systematic description of the form, organization, and dimensionality of visual inputs to the brain.
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A Small-Molecule Photoactivatable Optical Sensor of Transmembrane Potential.
TL;DR: The combination of cellular specificity achieved through spatially defined patterns of illumination, coupled with the fast, sensitive, and noncapacitive voltage sensing characteristics of VF dyes makes SPOT2.1.
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Functional imaging in the zebrafish retinotectal system using RGECO
TL;DR: It is shown that SyRGECO and RGECO are can report neural activity in vivo and that RG ECO expression permits detailed structural analysis of neuronal arbors, and these results open up the possibility of using zebrafish to functionally image genetically defined pre- and postsynaptic circuit components, separable by color, which will be a powerful approach to studying neural interactions in the brain.