A
Allan J. McLean
Researcher at University of Melbourne
Publications - 120
Citations - 9928
Allan J. McLean is an academic researcher from University of Melbourne. The author has contributed to research in topics: Pharmacokinetics & Perisinusoidal space. The author has an hindex of 34, co-authored 120 publications receiving 9644 citations. Previous affiliations of Allan J. McLean include Alfred Hospital & Royal Melbourne Hospital.
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Journal ArticleDOI
Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels
Andrew Tonkin,P. Alyward,David Colquhoun,Paul Glasziou,P. Harris,D. Hunt,Anthony C Keech,Stephen MacMahon,P. Magnus,D. Newel,P. Nestel,N. Sharpe,J. Shaw,R. J. Simes,P. Thompson,Alexis A. Thompson,Malcolm J. West,H. White,S. Simes,Wendy Hague,Sue Caleo,Jane Hall,Andrew J. Martin,S. Mulray,Philip J. Barter,Lawrence J. Beilin,Rory Collins,John J McNeil,Petra Meier,H. Willimott,D. Smithers,P. Wallace,J. Baker,M. Hobbs,David R. Sullivan,N. Anderson,Graeme J. Hankey,John D.G. Watson,M. Arulchelvam,S. Chup,John Daly,J. Hanna,A. Leach,M. Lee,J. Loughhead,H. Lundie-Jenkin,J. Morrison,S. Netting,A. Nguyen,H. Pater,R. Philip,G. Pinna,D. Rattos,S. Ryerson,V. Sazhin,Richard Walsh,A. Claque,M. Mackie,Julie Jane Yallop,K. Boss,M. Shepard,J. Leach,M. Gandy,J. Joughin,J. Seabrook,R. Abraham,J. Allen,F. Bates,I. Beinart,E. Breed,D. Brown,N. Bunyan,D. Calvert,T. Campbell,D. Condon-Paoloni,B. Conway,Lucy A. Coupland,J. Crowe,N. Cunio,B. Cuthbert,N. Cuthbert,S. D'Arcy,Patricia M. Davidson,B. Dwyer,J. England,C. Friend,Greg Fulcher,S. Grant,K. Hellestrand,M. Kava,Leonard Kritharides,D. McGill,H. McKee,Allan J. McLean,M. Neaverson,G. Nelson,M. O'Neill,C. Onuma,F. O'Reilly +98 more
TL;DR: Pravastatin therapy reduced mortality from coronary heart disease and overall mortality, as compared with the rates in the placebo group, as well as the incidence of all prespecified cardiovascular events in patients with a history of myocardial infarction or unstable angina who had a broad range of initial cholesterol levels.
Journal ArticleDOI
Aging Biology and Geriatric Clinical Pharmacology
TL;DR: A deficient therapeutic evidence base suggests that extrapolation of risk-benefit ratios from younger adults to geriatric populations is not necessarily valid, and therapeutic advances generally may convert healthy longevity from an asset of fortunate individuals into a general social benefit.
Journal ArticleDOI
The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis.
D. G. Le Couteur,Allan J. McLean +1 more
TL;DR: A review of age-related change in drug clearances established that patterns of change are not simply explained in terms of hepatic blood flow, hepatic mass and protein binding changes, and the reduction in clearances of high extraction drugs does correlate with observed reduction in hepatic perfusion.
Journal ArticleDOI
Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update.
Denis J. Morgan,Allan J. McLean +1 more
TL;DR: Clinical data are substantially consistent with the latter 2 theories, which regard the decreased permeability of the capillarised sinusoid as the critical feature in cirrhosis, and further work is required to determine the applicability of each of these theories.
Journal ArticleDOI
Pesticides and Parkinson's disease.
TL;DR: The simplest mechanistic hypothesis for the association of pesticides with Parkinson's disease is that pesticides or their metabolites are directly toxic to mitochondria, although modulation of xenobiotic metabolism by pesticides provides an adjunct or alternative hypothesis.