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Allan M. Gurtan
Researcher at Massachusetts Institute of Technology
Publications - 8
Citations - 979
Allan M. Gurtan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: microRNA & Regulation of gene expression. The author has an hindex of 7, co-authored 8 publications receiving 913 citations.
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Journal ArticleDOI
The role of miRNAs in regulating gene expression networks.
Allan M. Gurtan,Phillip A. Sharp +1 more
TL;DR: This work reviews mammalian miRNAs by describing recent advances in understanding their molecular activity and network-wide function and describes the technical challenges facing the network-based study of miRNA study.
The Role of miRNAs in Regulating Gene Expression Networks
Allan M. Gurtan,Phillip A. Sharp +1 more
TL;DR: In this article, the authors review mammalian miRNAs by describing recent advances in understanding their molecular activity and network-wide function, and describe how they are conserved across species, expressed across cell types, and active against a large proportion of the transcriptome.
Journal ArticleDOI
In vivo structure–function analysis of human Dicer reveals directional processing of precursor miRNAs
TL;DR: It is suggested that mutation of the clinically relevant residue D1709 within the RNase IIIB results in a uniquely miRNA-haploinsufficient state in which the let-7 family of tumor suppressor miRNAs is lost while a complement of 3p-derived mi RNAs remains expressed.
Journal ArticleDOI
Elucidating microRNA regulatory networks using transcriptional, post-transcriptional and histone modification measurements
Sara J. C. Gosline,Allan M. Gurtan,Courtney K. JnBaptiste,Andrew D. Bosson,Pamela Milani,Simona Dalin,Bryan J. Matthews,Yoon S. Yap,Phillip A. Sharp,Ernest Fraenkel +9 more
TL;DR: In this article, an approach to characterizing miRNA-regulatory networks by systematically profiling transcriptional, post-transcriptional and epigenetic activity in a pair of isogenic murine fibroblast cell lines with and without Dicer expression is described.
Journal ArticleDOI
Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1.
Arvind Ravi,Allan M. Gurtan,Madhu S. Kumar,Arjun Bhutkar,Christine Chin,Victoria Lu,Jacqueline A. Lees,Tyler Jacks,Phillip A. Sharp +8 more
TL;DR: In this paper, transformed or immortalized Dicer1 null somatic cells can be isolated readily in vitro, maintain the characteristics of DICER1-expressing controls and remain stably proliferative.