Arjun Bhutkar

TL;DR: These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution.

TL;DR: It is found that acquired resistance to Kras suppression in a Kras-driven murine lung cancer model also involved increased YAP1 signaling, which implicate transcriptional regulation of EMT by Yap1 as a significant component of oncogenic RAS signaling.

TL;DR: In this paper, the authors provide evidence that local microbiota provoke inflammation associated with lung adenocarcinoma by activating lung resident γδ T cells, and link local microbiota-immune crosstalk to lung tumor development and define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.

TL;DR: In this article, a combination of CRISPR-Cas9-based genetic screening and metabolomic analyses was used to identify mutations in the KEAP1 gene encoding Kelch-like ECH-associated protein 1 (KEAP1), a negative regulator of nuclear factor erythroid 2-like 2 (NFE2L2), which is the master transcriptional regulator of the endogenous antioxidant response.

TL;DR: It is concluded that poly(ADP-ribose) is a key regulator of posttranscriptional gene expression in the cytoplasm, which accumulate RNA-binding proteins that regulate the translation and stability of mRNAs upon stress.