Mapping the vast quantities of short sequence fragments produced by next-generation sequencing platforms is a challenge. What programs are available and how do they work?

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How to map billions of short reads onto

Processing-using-DRAM has been proposed for a limited set of basic operations (i.e., logic operations, addition). However, in order to enable full adoption of processing-using-DRAM, it is necessary to provide support for more complex operations. In this paper, we propose SIMDRAM, a flexible general-purpose processing-using-DRAM framework that (1) enables the efficient implementation of complex operations, and (2) provides a flexible mechanism tosupport the implementation of arbitrary user-defined operations. The SIMDRAM framework comprises three key steps. The first step builds an efficient MAJ/NOT representation of a given desired operation. The second step allocates DRAM rows that are reserved for computation to the operation’s input and output operands, and generates the required sequence of DRAM commands to perform the MAJ/NOT implementation of the desired operation in DRAM. The third step uses the SIMDRAM control unit located inside the memory controller to manage the computation of the operation from start to end, by executing the DRAM commands generated in the second step of the framework. We design the hardware and ISA support for SIMDRAM framework to (1) address key system integration challenges, and (2) allow programmers to employ new SIMDRAM operations without hardware changes. We evaluate SIMDRAM for reliability, area overhead, throughput, and energy efficiency using a wide range of operations and seven real-world applications to demonstrate SIMDRAM’s generality. Our evaluations using a single DRAM bank show that (1) over 16 operations, SIMDRAM provides 2.0X the throughput and 2.6X the energy efficiency of Ambit, a state-of-the-art processing-using-DRAM mechanism; (2) over seven real-world applications, SIMDRAM provides 2.5X the performance of Ambit. Using 16 DRAM banks, SIMDRAM provides (1) 88X and 5.8X the throughput, and 257X and 31X the energy efficiency, of a CPU and a high-end GPU, respectively, over 16 operations; (2) 21X and 2.1X the performance of the CPU and GPU, over seven real-world applications. SIMDRAM incurs an area overhead of only 0.2% in a high-end CPU.

SIMDRAM: a framework for bit-serial SIMD processing using DRAM

Modern computing systems are overwhelmingly designed to move data to computation. This design choice goes directly against at least three key trends in computing that cause performance, scalability and energy bottlenecks: (1) data access is a key bottleneck as many important applications are increasingly data-intensive, and memory bandwidth and energy do not scale well, (2) energy consumption is a key limiter in almost all computing platforms, especially server and mobile systems, (3) data movement, especially off-chip to on-chip, is very expensive in terms of bandwidth, energy and latency, much more so than computation. These trends are especially severely-felt in the data-intensive server and energy-constrained mobile systems of today. At the same time, conventional memory technology is facing many technology scaling challenges in terms of reliability, energy, and performance. As a result, memory system architects are open to organizing memory in different ways and making it more intelligent, at the expense of higher cost. The emergence of 3D-stacked memory plus logic, the adoption of error correcting codes inside the latest DRAM chips, proliferation of different main memory standards and chips, specialized for different purposes (e.g., graphics, low-power, high bandwidth, low latency), and the necessity of designing new solutions to serious reliability and security issues, such as the RowHammer phenomenon, are an evidence of this trend. This chapter discusses recent research that aims to practically enable computation close to data, an approach we call processing-in-memory (PIM). PIM places computation mechanisms in or near where the data is stored (i.e., inside the memory chips, in the logic layer of 3D-stacked memory, or in the memory controllers), so that data movement between the computation units and memory is reduced or eliminated.

A Modern Primer on Processing in Memory.

Data movement between the CPU and main memory is a first-order obstacle against improv ing performance, scalability, and energy efficiency in modern systems. Computer systems employ a range of techniques to reduce overheads tied to data movement, spanning from traditional mechanisms (e.g., deep multi-level cache hierarch ies, aggressive hardware prefetcher s) to emerging techniques such as Near-Data Processing (NDP), where some computation is moved close to memory. Prior NDP works investigate the root causes of data movement bottlenecks using different profiling methodologies and tools. However, there is still a lack of understanding about the key metrics that can identify different data movement bottlenecks and their relation to traditional and emerging data movement mitigation mechanisms. Our goal is to methodically identify potential sources of data movement over a broad set of applications and to comprehensively compare traditional compute-centric data movement mitigation techniques (e.g., cach ing and prefetch ing) to more memory-centric techniques (e.g., NDP), thereby developing a rigorous understanding of the best techniques to mitigate each source of data movement. With this goal in mind, we perform the first large-scale characterization of a wide variety of applications, across a wide range of application domains, to identify fundamental program properties that lead to data movement to/from main memory. We develop the first systematic methodology to classify applications based on the sources contributing to data movement bottlenecks. From our large-scale characterization of 77K functions across 345 applications, we select 144 functions to form the first open-source benchmark suite (DAMOV) for main memory data movement studies. We select a diverse range of functions that (1) represent different types of data movement bottlenecks, and (2) come from a wide range of application domains. Using NDP as a case study, we identify new insights about the different data movement bottlenecks and use these insights to determine the most suitable data movement mitigation mechanism for a particular application. We open-source DAMOV and the complete source code for our new characterization methodology at https://github.com/CMU-SAFARI/DAMOV .

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DAMOV: A New Methodology and Benchmark Suite for Evaluating Data Movement Bottlenecks

Time series analysis is a key technique for extracting and predicting events in domains as diverse as epidemiology, genomics, neuroscience, environmental sciences, economics, and more. Matrix profile, the state-of-the-art algorithm to perform time series analysis, computes the most similar subsequence for a given query subsequence within a sliced time series. Matrix profile has low arithmetic intensity, but it typically operates on large amounts of time series data. In current computing systems, this data needs to be moved between the off-chip memory units and the on-chip computation units for performing matrix profile. This causes a major performance bottleneck as data movement is extremely costly in terms of both execution time and energy. 
In this work, we present NATSA, the first Near-Data Processing accelerator for time series analysis. The key idea is to exploit modern 3D-stacked High Bandwidth Memory (HBM) to enable efficient and fast specialized matrix profile computation near memory, where time series data resides. NATSA provides three key benefits: 1) quickly computing the matrix profile for a wide range of applications by building specialized energy-efficient floating-point arithmetic processing units close to HBM, 2) improving the energy efficiency and execution time by reducing the need for data movement over slow and energy-hungry buses between the computation units and the memory units, and 3) analyzing time series data at scale by exploiting low-latency, high-bandwidth, and energy-efficient memory access provided by HBM. Our experimental evaluation shows that NATSA improves performance by up to 14.2x (9.9x on average) and reduces energy by up to 27.2x (19.4x on average), over the state-of-the-art multi-core implementation. NATSA also improves performance by 6.3x and reduces energy by 10.2x over a general-purpose NDP platform with 64 in-order cores.

NATSA: A Near-Data Processing Accelerator for Time Series Analysis

Genome sequence analysis has enabled significant advancements in medical and scientific areas such as personalized medicine, outbreak tracing, and the understanding of evolution. To perform genome sequencing, devices extract small random fragments of an organism’s DNA sequence (known as reads). The first step of genome sequence analysis is a computational process known as read mapping. In read mapping, each fragment is matched to its potential location in the reference genome with the goal of identifying the original location of each read in the genome. Unfortunately, rapid genome sequencing is currently bottlenecked by the computational power and memory bandwidth limitations of existing systems, as many of the steps in genome sequence analysis must process a large amount of data. A major contributor to this bottleneck is approximate string matching (ASM), which is used at multiple points during the mapping process. ASM enables read mapping to account for sequencing errors and genetic variations in the reads.We propose GenASM, the first ASM acceleration framework for genome sequence analysis. GenASM performs bitvectorbased ASM, which can efficiently accelerate multiple steps of genome sequence analysis. We modify the underlying ASM algorithm (Bitap) to significantly increase its parallelism and reduce its memory footprint. Using this modified algorithm, we design the first hardware accelerator for Bitap. Our hardware accelerator consists of specialized systolic-array-based compute units and on-chip SRAMs that are designed to match the rate of computation with memory capacity and bandwidth, resulting in an efficient design whose performance scales linearly as we increase the number of compute units working in parallel.We demonstrate that GenASM provides significant performance and power benefits for three different use cases in genome sequence analysis. First, GenASM accelerates read alignment for both long reads and short reads. For long reads, GenASM outperforms state-of-the-art software and hardware accelerators by 116× and 3.9×, respectively, while reducing power consumption by 37× and 2.7×. For short reads, GenASM outperforms state-of-the-art software and hardware accelerators by 111× and 1.9×. Second, GenASM accelerates pre-alignment filtering for short reads, with 3.7× the performance of a state-of-the-art pre-alignment filter, while reducing power consumption by 1.7× and significantly improving the filtering accuracy. Third, GenASM accelerates edit distance calculation, with 22–12501× and 9.3–400× speedups over the state-of-the-art software library and FPGA-based accelerator, respectively, while reducing power consumption by 548–582× and 67×. We conclude that GenASM is a flexible, high-performance, and low-power framework, and we briefly discuss four other use cases that can benefit from GenASM.

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GenASM: A High-Performance, Low-Power Approximate String Matching Acceleration Framework for Genome Sequence Analysis

Genome sequence analysis has enabled significant advancements in medical and scientific areas such as personalized medicine, outbreak tracing, and the understanding of evolution. Unfortunately, it is currently bottlenecked by the computational power and memory bandwidth limitations of existing systems, as many of the steps in genome sequence analysis must process a large amount of data. A major contributor to this bottleneck is approximate string matching (ASM). 
We propose GenASM, the first ASM acceleration framework for genome sequence analysis. We modify the underlying ASM algorithm (Bitap) to significantly increase its parallelism and reduce its memory footprint, and we design the first hardware accelerator for Bitap. Our hardware accelerator consists of specialized compute units and on-chip SRAMs that are designed to match the rate of computation with memory capacity and bandwidth. 
We demonstrate that GenASM is a flexible, high-performance, and low-power framework, which provides significant performance and power benefits for three different use cases in genome sequence analysis: 1) GenASM accelerates read alignment for both long reads and short reads. For long reads, GenASM outperforms state-of-the-art software and hardware accelerators by 116x and 3.9x, respectively, while consuming 37x and 2.7x less power. For short reads, GenASM outperforms state-of-the-art software and hardware accelerators by 111x and 1.9x. 2) GenASM accelerates pre-alignment filtering for short reads, with 3.7x the performance of a state-of-the-art pre-alignment filter, while consuming 1.7x less power and significantly improving the filtering accuracy. 3) GenASM accelerates edit distance calculation, with 22-12501x and 9.3-400x speedups over the state-of-the-art software library and FPGA-based accelerator, respectively, while consuming 548-582x and 67x less power.

Allison Scibisz

Papers

GenASM: A High-Performance, Low-Power Approximate String Matching Acceleration Framework for Genome Sequence Analysis

GenASM: A High-Performance, Low-Power Approximate String Matching Acceleration Framework for Genome Sequence Analysis