Alok Upadhyay

TL;DR: Surprisingly, unconjugated naked PNA(TAR) displayed a similar distribution and clearance profile in most organs studied although extent of its uptake was lower than the PNA (TAR)-CPP conjugate, which exhibits strong antiviral and anti-HIV-1 virucidal activities.

TL;DR: Small interfering RNA-mediated silencing of a diverse class of selected proteins in an HCV replicon cell line either enhanced or inhibitedHCV replication/translation, suggesting that these cellular factors have regulatory roles in HCV replication.

TL;DR: The present and future therapeutic potential of this class of compound as anti-HIV-1 drugs as well as potential antisense drugs are discussed.

TL;DR: The data presented herein indicates that any perturbation in the β7-β8 loop of the p51 subunit of HIV-1 RT affects the dimerization process resulting in substantial loss of DNA binding ability and catalytic function of the enzyme.

TL;DR: It is demonstrated that naked PNA(TAR) is immunologically inert as judged by the proliferation responses of splenocytes and lymph node cells from PNA (TAR)-immunized mice challenged with the immunizing antigen, and the favorable immunological response together with negligible toxicity suggest a strong therapeutic potential for this class of compounds.