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Álvaro del Real
Researcher at University of Cantabria
Publications - 22
Citations - 228
Álvaro del Real is an academic researcher from University of Cantabria. The author has contributed to research in topics: Epigenetics & Medicine. The author has an hindex of 7, co-authored 16 publications receiving 164 citations. Previous affiliations of Álvaro del Real include University of Murcia & University of Oviedo.
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Journal ArticleDOI
Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis
Álvaro del Real,Flor M. Pérez-Campo,Agustín F. Fernández,Carolina Sañudo,Carmen García Ibarbia,María I. Pérez-Núñez,Wim Van Criekinge,Maarten Braspenning,María A. Alonso,Mario F. Fraga,José A. Riancho +10 more
TL;DR: 2 areas of potential interest for discovering new therapeutic targets for low bone mass disorders and bone regeneration are pointed to: the mechanisms stimulating MSCs proliferation after fracture and those impairing their terminal differentiation.
Journal ArticleDOI
Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells
Estela G. Toraño,Gustavo F. Bayón,Álvaro del Real,Marta I. Sierra,María Begoña González García,Antonella Carella,Thalia Belmonte,Rocío G. Urdinguio,Isabel Cubillo,Javier García-Castro,Jesus Delgado-Calle,Flor M. Pérez-Campo,José A. Riancho,Mario F. Fraga,Agustín F. Fernández +14 more
TL;DR: DNA hyper-hydroxymethylation in the advanced-age group was associated with loss of 5mC, which suggests that, at specific CpG sites, this epigenetic modification might play a role in DNA methylation changes during lifetime.
Journal ArticleDOI
Specific premature epigenetic aging of cartilage in osteoarthritis
Laura Vidal-Bralo,Yolanda Lopez-Golan,Antonio Mera-Varela,Ignacio Rego-Pérez,Steve Horvath,Yuhua Zhang,Álvaro del Real,Guangju Zhai,Francisco J. Blanco,José A. Riancho,Juan J. Gomez-Reino,Antonio Gonzalez +11 more
TL;DR: Premature epigenetic aging according to DNA methylation changes was specific of OA cartilage, adding further evidence and insight on premature aging of cartilage as a component of Oa pathogenesis that reflects damage and vulnerability.
Journal ArticleDOI
Epigenetics of Skeletal Diseases
TL;DR: The role of epigenetic mechanisms in bone biology and pathology is provided, which helps to explain the mechanisms by which prenatal and post-natal external factors impact the authors' body and influence the risk of later disease.
Journal ArticleDOI
How to interpret epigenetic association studies: a guide for clinicians
TL;DR: This report proposes a framework to help in the critical appraisal of epigenetic association studies and focuses on the questions critical to appraise the validity of the study, to interpret the results and to assess the generalizability and relevance of the information.