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Estela G. Toraño
Researcher at University of Oviedo
Publications - 12
Citations - 583
Estela G. Toraño is an academic researcher from University of Oviedo. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 10, co-authored 12 publications receiving 486 citations. Previous affiliations of Estela G. Toraño include International Sleep Products Association.
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Journal ArticleDOI
Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility
Rocío G. Urdinguio,Gustavo F. Bayón,Marija Dmitrijeva,Estela G. Toraño,Cristina Bravo,Mario F. Fraga,Lluís Bassas,Sara Larriba,Agustín F. Fernández +8 more
TL;DR: The data suggest that aberrant sperm DNA methylation might contribute to fertility impairment in couples with unexplained infertility and they provide a promising basis for future research.
Journal ArticleDOI
H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cells
Agustín F. Fernández,Gustavo F. Bayón,Rocío G. Urdinguio,Estela G. Toraño,María Begoña González García,Antonella Carella,Sandra Petrus-Reurer,Cecilia Ferrero,Pablo Martínez-Camblor,Isabel Cubillo,Javier García-Castro,Jesus Delgado-Calle,Flor M. Pérez-Campo,José A. Riancho,Clara Bueno,Pablo Menendez,Anouk Mentink,Katia Mareschi,Katia Mareschi,Fabian Claire,Corrado Fagnani,Emanuela Medda,Virgilia Toccaceli,Sonia Brescianini,Sebastian Moran,Manel Esteller,Alexandra Stolzing,Alexandra Stolzing,Jan de Boer,Jan de Boer,Lorenza Nisticò,Maria Antonietta Stazi,Mario F. Fraga,Mario F. Fraga +33 more
TL;DR: The results indicate that the dynamics of DNA methylation during aging depend on a complex mixture of factors that include the DNA sequence, cell type, and chromatin context involved and that, depending on the locus, the changes can be modulated by genetic and/or external factors.
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Global DNA hypomethylation in cancer: review of validated methods and clinical significance.
TL;DR: This work reviews some of the techniques for the analysis of DNA methylation using different approaches: global, locus-specific, or genome-wide and discusses their potential clinical utility.
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The Impact of External Factors on the Epigenome: In Utero and over Lifetime
Estela G. Toraño,María Begoña González García,Juan Luis Fernández-Morera,Pilar Niño-García,Agustín F. Fernández +4 more
TL;DR: How chemical and physical environmental stressors, diet, life habits, and pharmacological treatments can affect the epigenome during lifetime and the possible impact of these epigenetic changes on pathophysiological processes are discussed.
Journal ArticleDOI
Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells
Estela G. Toraño,Gustavo F. Bayón,Álvaro del Real,Marta I. Sierra,María Begoña González García,Antonella Carella,Thalia Belmonte,Rocío G. Urdinguio,Isabel Cubillo,Javier García-Castro,Jesus Delgado-Calle,Flor M. Pérez-Campo,José A. Riancho,Mario F. Fraga,Agustín F. Fernández +14 more
TL;DR: DNA hyper-hydroxymethylation in the advanced-age group was associated with loss of 5mC, which suggests that, at specific CpG sites, this epigenetic modification might play a role in DNA methylation changes during lifetime.