G
Guangju Zhai
Researcher at Memorial University of Newfoundland
Publications - 157
Citations - 26851
Guangju Zhai is an academic researcher from Memorial University of Newfoundland. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 60, co-authored 148 publications receiving 24825 citations. Previous affiliations of Guangju Zhai include University of London & St Thomas' Hospital.
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Journal ArticleDOI
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis,Josée Dupuis,Claudia Langenberg,Inga Prokopenko,Richa Saxena,Richa Saxena,Nicole Soranzo,Nicole Soranzo,Anne U. Jackson,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Anna L. Gloyn,Cecilia M. Lindgren,Reedik Mägi,Andrew P. Morris,Joshua C. Randall,Toby Johnson,Toby Johnson,Paul Elliott,Paul Elliott,Denis Rybin,Gudmar Thorleifsson,Valgerdur Steinthorsdottir,Peter Henneman,Harald Grallert,Abbas Dehghan,Jouke JanHottenga,Christopher S. Franklin,Pau Navarro,Kijoung Song,Anuj Goel,John R. B. Perry,Josephine M. Egan,Taina K. Lajunen,Niels Grarup,Thomas Sparsø,Alex S. F. Doney,Benjamin F. Voight,Benjamin F. Voight,Heather M. Stringham,Man Li,Stavroula Kanoni,Peter Shrader,Christine Cavalcanti-Proença,Meena Kumari,Lu Qi,Nicholas J. Timpson,Christian Gieger,Carina Zabena,Ghislain Rocheleau,Erik Ingelsson,Erik Ingelsson,Ping An,Jeffrey R. O'Connell,Jian'an Luan,Amanda F. Elliott,Amanda F. Elliott,Steven A. McCarroll,Steven A. McCarroll,Felicity Payne,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Kristin Ardlie,Yavuz Ariyurek,Beverley Balkau,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Rafn Benediktsson,Amanda J. Bennett,Sven Bergmann,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Amélie Bonnefond,Lori L. Bonnycastle,Knut Borch-Johnsen,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Suzannah Bumpstead,Guillaume Charpentier,Yii Der IdaChen,Peter S. Chines,Robert Clarke,Lachlan J. McOin,Mark E. Cooper,Marilyn C. Cornelis,Gabe Crawford,Laura Crisponi,Ian N. M. Day,Eco J. C. de Geus,Jérôme Delplanque,Christian Dina,Michael R. Erdos,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,Caroline S. Fox,Caroline S. Fox,Rune R. Frants,Maria GraziaFranzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,Christopher J. Groves,Scott M. Grundy,Rhian Gwilliam,Ulf Gyllensten,Samy Hadjadj,Göran Hallmans,Naomi Hammond,Xijing Han,Anna LiisaHartikainen,Neelam Hassanali,Caroline Hayward,Simon Heath,Serge Hercberg,Christian Herder,Andrew A. Hicks,David R. Hillman,Aroon D. Hingorani,Albert Hofman,Jennie Hui,Joseph Hung,Joseph Hung,Bo Isomaa,Paul Johnson,Torben Jørgensen,Antti Jula,Marika Kaakinen,Jaakko Kaprio,Jaakko Kaprio,Y. AnteroKesaniemi,Mika Kivimäki,Beatrice Knight,Seppo Koskinen,Peter Kovacs,Kirsten Ohm Kyvik,G. Mark Lathrop,Debbie A Lawlor,Olivier Le Bacquer,Cécile Lecoeur,Yun Li,Valeriya Lyssenko,Robert W. Mahley,Massimo Mangino,Alisa K. Manning,María TeresaMartínez-Larrad,Jarred B. McAteer,Jarred B. McAteer,Laura J. McCulloch,Ruth McPherson,Christa Meisinger,David Melzer,David Meyre,Braxton D. Mitchell,Mario A. Morken,Sutapa Mukherjee,Silvia Naitza,Narisu Narisu,Matt Neville,Ben A. Oostra,Marco Orrù,Ruth E. Pakyz,Colin N. Apalmer,Giuseppe Paolisso,Cristian Pattaro,Daniel S. Pearson,John F. Peden,Nancy L. Pedersen,Markus Perola,Markus Perola,Andreas Pfeiffer,Irene Pichler,Ozren Polasek,Danielle Posthuma,Simon C. Potter,Anneli Pouta,Michael A. Province,Bruce M. Psaty,Bruce M. Psaty,Wolfgang Rathmann,Nigel W. Rayner,Kenneth Rice,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Michael Roden,Olov Rolandsson,Annelli Sandbæk,Manjinder S. Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Laura J. Scott,Udo Seedorf,Stephen J. Sharp,Beverley M. Shields,Gunnar Sigursson,Eric J.G. Sijbrands,Angela Silveira,Laila Simpson,Andrew B. Singleton,Nicholas L. Smith,Nicholas L. Smith,Ulla Sovio,Amy J. Swift,Holly E. Syddall,Ann ChristineSyvänen,Toshiko Tanaka,Toshiko Tanaka,Barbara Thorand,Jean Tichet,Anke Tönjes,Tiinamaija Tuomi,André G. Uitterlinden,Ko Willems van Dijk,Mandy van Hoek,Dhiraj Varma,Sophie Visvikis-Siest,Veronique Vitart,Nicole Vogelzangs,Gerard Waeber,Peter Wagner,Peter Wagner,Andrew Walley,G. BragiWalters,Kim L. Ward,Hugh Watkins,Michael N. Weedon,Sarah H. Wild,Gonneke Willemsen,Jaqueline C. MWitteman,John W. GYarnell,Eleftheria Zeggini,Eleftheria Zeggini,Diana Zelenika,Björn Zethelius,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M. Carola Zillikens,Ingrid B. Borecki,Ruth J. F. Loos,Pierre Meneton,Patrik K. E. Magnusson,David M. Nathan,Gordon H. Williams,Andrew T. Hattersley,Kaisa Silander,Kaisa Silander,Veikko Salomaa,George Davey Smith,Stefan R. Bornstein,Peter Schwarz,Joachim Spranger,Fredrik Karpe,Alan R. Shuldiner,Cyrus Cooper,George Dedoussis,Manuel Serrano-Ríos,Andrew D. Morris,Lars Lind,Lyle J. Palmer,Lyle J. Palmer,Frank B. Hu,Paul W. Franks,Shah Ebrahim,Michael Marmot,W. H. Linda Kao,James S. Pankow,Mike Sampson,Johanna Kuusisto,Markku Laakso,Torben Hansen,Torben Hansen,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Peter P. Pramstaller,H.-Erich Wichmann,Thomas Illig,Igor Rudan,Igor Rudan,Alan F. Wright,Michael Stumvoll,Harry Campbell,James F. Wilson,Richard N. Bergman,Thomas A. Buchanan,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Jaakko Tuomilehto,Timo T. Valle,David Altshuler,David Altshuler,Jerome I. Rotter,David S. Siscovick,Brenda W.J.H. Penninx,Dorret I. Boomsma,Panos Deloukas,Tim D. Spector,Tim D. Spector,Timothy M. Frayling,Luigi Ferrucci,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson,Cornelia M. van Duijn,Yurii S. Aulchenko,Antonio Cao,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Marjo Riitta-Järvelin,Marjo Riitta-Järvelin,Dawn M. Waterworth,Peter Vollenweider,Leena Peltonen,Vincent Mooser,Gonçalo R. Abecasis,Nicholas J. Wareham,Robert Sladek,Philippe Froguel,Philippe Froguel,Richard M. Watanabe,James B. Meigs,Leif Groop,Michael Boehnke,Mark I. McCarthy,Jose C. Florez,Jose C. Florez,Inês Barroso +339 more
TL;DR: It is demonstrated that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes.
Journal ArticleDOI
A genome-wide association search for type 2 diabetes genes in African Americans.
Nichole D. Palmer,Caitrin W. McDonough,Pamela J. Hicks,B H Roh,M R Wing,S S An,Jessica M. Hester,Jessica N. Cooke,Meredith A. Bostrom,Megan E. Rudock,Matthew E. Talbert,Joshua P. Lewis,Assiamira Ferrara,Lingyi Lu,Julie T. Ziegler,Michèle M. Sale,Jasmin Divers,Daniel Shriner,Adebowale Adeyemo,Charles N. Rotimi,Ng Mcy.,Carl D. Langefeld,Barry I. Freedman,Donald W. Bowden,Benjamin F. Voight,Laura J. Scott,Valgerdur Steinthorsdottir,Andrew P. Morris,Christian Dina,Ryan P. Welch,Eleftheria Zeggini,Cornelia Huth,Yurii S. Aulchenko,Gudmar Thorleifsson,Laura J. McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,Guanming Wu,Cristen J. Willer,Soumya Raychaudhuri,Steven A. McCarroll,Claudia Langenberg,O M Hofmann,Josée Dupuis,Lu Qi,A V Segrè,M. van Hoek,Pau Navarro,Kristin G. Ardlie,Beverley Balkau,Rafn Benediktsson,Amanda J. Bennett,Roza Blagieva,Eric Boerwinkle,Lori L. Bonnycastle,Kristina Bengtsson Boström,Bert Bravenboer,Suzannah Bumpstead,N P Burtt,Guillaume Charpentier,Peter S. Chines,Marilyn C. Cornelis,David Couper,Gabriel Crawford,Doney Asf.,Kathryn Elliott,A L Elliott,Michael R. Erdos,Caroline S. Fox,Christopher S. Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Simon J. Griffin,C J Groves,Candace Guiducci,Samy Hadjadj,N Hassanali,C. Herder,Bo Isomaa,Anne U. Jackson,Johnson Prv.,Torben Jørgensen,Kao Whl.,N Klopp,Augustine Kong,Peter Kraft,Johanna Kuusisto,Torsten Lauritzen,Man Li,Aloysius G Lieverse,Cecilia M. Lindgren,Valeriya Lyssenko,Meghan L. Marré,Thomas Meitinger,Kristian Midthjell,Mario A. Morken,Narisu Narisu,P. M. Nilsson,Katharine R. Owen,Felicity Payne,Perry Jrb.,Petersen A-K.,Carl G. P. Platou,Christine Proença,Inga Prokopenko,Wolfgang Rathmann,N W Rayner,Neil R. Robertson,Ghislain Rocheleau,Michael Roden,Mike Sampson,Richa Saxena,B M Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M. Stringham,Qi Sun,Amy J. Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,R. M. van Dam,T.W. van Haeften,T van Herpt,J. V. van Vliet-Ostaptchouk,G B Walters,Michael N. Weedon,Cisca Wijmenga,Jacqueline C. M. Witteman,Richard N. Bergman,Stéphane Cauchi,Francis S. Collins,Anna L. Gloyn,Ulf Gyllensten,Torben Hansen,Winston Hide,Graham A. Hitman,Albert Hofman,David J. Hunter,Kristian Hveem,Markku Laakso,Karen L. Mohlke,Andrew D. Morris,Palmer Cna.,Peter P. Pramstaller,Igor Rudan,Eric J.G. Sijbrands,Lincoln D. Stein,Jaakko Tuomilehto,A.G. Uitterlinden,M Walker,Nicholas J. Wareham,Richard M. Watanabe,Gonçalo R. Abecasis,Bernhard O. Boehm,Harry Campbell,Mark J. Daly,Andrew T. Hattersley,Frank B. Hu,James B. Meigs,James S. Pankow,Oluf Pedersen,Wichmann H-E.,Inês Barroso,Jose C. Florez,Timothy M. Frayling,Leif Groop,R Sladek,Unnur Thorsteinsdottir,James F. Wilson,Thomas Illig,Philippe Froguel,C M van Duijn,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I. McCarthy,Nicole Soranzo,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Reedik Mägi,Joshua C. Randall,Toby Johnson,Paul Elliott,Denis Rybin,Peter Henneman,Abbas Dehghan,Jouke-Jan Hottenga,Kijoung Song,Anuj Goel,Josephine M. Egan,Taina K. Lajunen,Alex S. F. Doney,Stavroula Kanoni,Christine Cavalcanti-Proença,Meena Kumari,Nicholas J. Timpson,Carina Zabena,Erik Ingelsson,Ping An,Jeffrey R. O'Connell,Jian'an Luan,Amanda F. Elliott,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Yavuz Ariyurek,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Sven Bergmann,Murielle Bochud,Amélie Bonnefond,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Suzannah Bumpstead,Chen Y-Di.,Peter S. Chines,Robert Clarke,Coin Ljm.,Mark E. Cooper,Laura Crisponi,Day Inm.,de Geus Ejc.,Jérôme Delplanque,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,R.R. Frants,MariaGrazia Franzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,Scott M. Grundy,R. Gwilliam,Göran Hallmans,Naomi Hammond,Xijing Han,Hartikainen A-L.,Caroline Hayward,Simon C. Heath,Serge Hercberg,Andrew A. Hicks,David R. Hillman,Aroon D. Hingorani,Jennie Hui,Joseph Hung,A. Jula,Marika Kaakinen,Jaakko Kaprio,Y A Kesaniemi,Mika Kivimäki,Beatrice Knight,Sini Koskinen,Peter Kovacs,Kirsten Ohm Kyvik,G M Lathrop,Debbie A Lawlor,O Le Bacquer,Cécile Lecoeur,Yun Li,Robert W. Mahley,Massimo Mangino,Alisa K. Manning,María Teresa Martínez-Larrad,Jarred B. McAteer,Ruth McPherson,Christine Meisinger,David Melzer,David Meyre,B. D. Mitchell,Sutapa Mukherjee,Silvia Naitza,Matt J. Neville,B.A. Oostra,Marco Orrù,Ruth E. Pakyz,Giuseppe Paolisso,C. Pattaro,D. Pearson,John F. Peden,Nancy L. Pedersen,M. Perola,Pfeiffer Afh.,Irene Pichler,Ozren Polašek,Danielle Posthuma,Simon C. Potter,Anneli Pouta,M. A. Province,Bruce M. Psaty,Kenneth Rice,Samuli Ripatti,F. Rivadeneira,Olov Rolandsson,A. Sandbaek,M. S. Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Udo Seedorf,Stephen J. Sharp,Beverley M. Shields,Sijbrands Ejg.,Angela Silveira,Laila Simpson,Andrew B. Singleton,Nicholas L. Smith,Ulla Sovio,A J Swift,H E Syddall,Syvänen A-C.,Toshiko Tanaka,Anke Tönjes,Andre G. Uitterlinden,K W van Dijk,Dhiraj Varma,Sophie Visvikis-Siest,Veronique Vitart,Nicole Vogelzangs,Gerard Waeber,P J Wagner,Andrew Walley,Kim L. Ward,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,Witteman Jcm.,Yarnell Jwg.,Diana Zelenika,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M. C. Zillikens,Ingrid B. Borecki,Loos Rjf.,Pierre Meneton,Magnusson Pke.,David M. Nathan,Gordon H. Williams,Kaisa Silander,Veikko Salomaa,George Davey Smith,Stefan R. Bornstein,Peter Schwarz,Jochen Spranger,F Karpe,Alan R. Shuldiner,Cyrus Cooper,George Dedoussis,Manuel Serrano-Ríos,Lars Lind,Lyle J. Palmer,Paul W. Franks,Shah Ebrahim,Michael Marmot,Alan F. Wright,Michael Stumvoll,Anders Hamsten,Thomas A. Buchanan,Timo T. Valle,Jerome I. Rotter,David S. Siscovick,Penninx Bwjh.,Dorret I. Boomsma,Panos Deloukas,Tim D. Spector,Luigi Ferrucci,Anyuan Cao,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Jarvelin M-R.,Dawn M. Waterworth,Peter Vollenweider,Leena Peltonen,Vincent Mooser +384 more
TL;DR: It is suggested that multiple loci underlie T2DM susceptibility in the African-American population and that these loci are distinct from those identified in other ethnic populations.
Journal ArticleDOI
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Georg Ehret,Georg Ehret,Georg Ehret,Patricia B. Munroe,Kenneth Rice,Murielle Bochud,Andrew D. Johnson,Daniel I. Chasman,Albert V. Smith,Martin D. Tobin,Germaine C. Verwoert,Shih-Jen Hwang,Vasyl Pihur,Peter Vollenweider,Paul F. O'Reilly,Najaf Amin,Jennifer L. Bragg-Gresham,Alexander Teumer,Nicole L. Glazer,Lenore J. Launer,Jing Hua Zhao,Yurii S. Aulchenko,Simon Heath,Siim Sõber,Afshin Parsa,Jian'an Luan,Pankaj Arora,Abbas Dehghan,Feng Zhang,Gavin Lucas,Andrew A. Hicks,Anne U. Jackson,John F. Peden,Toshiko Tanaka,Sarah H. Wild,Igor Rudan,Igor Rudan,Wilmar Igl,Yuri Milaneschi,Alex Parker,Cristiano Fava,Cristiano Fava,John C. Chambers,John C. Chambers,Ervin R. Fox,Meena Kumari,Min Jin Go,Pim van der Harst,Wen Hong Linda Kao,Marketa Sjögren,D. G. Vinay,Myriam Alexander,Yasuharu Tabara,Sue Shaw-Hawkins,Peter H. Whincup,Yongmei Liu,Gang Shi,Johanna Kuusisto,Bamidele O. Tayo,Mark Seielstad,Mark Seielstad,Xueling Sim,Khanh-Dung H. Nguyen,Terho Lehtimäki,Giuseppe Matullo,Ying Wu,Tom R. Gaunt,N. Charlotte Onland-Moret,Mark E. Cooper,Carl G. P. Platou,Elin Org,Rebecca Hardy,Santosh Dahgam,Jutta Palmen,Veronique Vitart,Peter S. Braund,Peter S. Braund,Tatiana Kuznetsova,Cuno S.P.M. Uiterwaal,Adebowale Adeyemo,Walter Palmas,Harry Campbell,Barbara Ludwig,Maciej Tomaszewski,Maciej Tomaszewski,Ioanna Tzoulaki,Ioanna Tzoulaki,Nicholette D. Palmer,Thor Aspelund,Melissa Garcia,Yen Pei C. Chang,Jeffrey R. O'Connell,Nanette I. Steinle,Diederick E. Grobbee,Dan E. Arking,Sharon L.R. Kardia,Alanna C. Morrison,Dena G. Hernandez,Samer S. Najjar,Samer S. Najjar,Wendy L. McArdle,David Hadley,David Hadley,Morris J. Brown,John M. C. Connell,Aroon D. Hingorani,Ian N. M. Day,Debbie A Lawlor,John Beilby,Robert W. Lawrence,Robert Clarke,Jemma C. Hopewell,Halit Ongen,Albert W. Dreisbach,Yali Li,J. Hunter Young,Joshua C. Bis,Mika Kähönen,Jorma Viikari,Linda S. Adair,Nanette R. Lee,Ming-Huei Chen,Matthias Olden,Cristian Pattaro,Judith A. Hoffman Bolton,Anna Köttgen,Anna Köttgen,Sven Bergmann,Sven Bergmann,Vincent Mooser,Nish Chaturvedi,Timothy M. Frayling,Muhammad Islam,Tazeen H. Jafar,Jeanette Erdmann,Smita R. Kulkarni,Stefan R. Bornstein,Jürgen Grässler,Leif Groop,Benjamin F. Voight,Johannes Kettunen,Philip Howard,Andrew M. Taylor,Simonetta Guarrera,Fulvio Ricceri,Valur Emilsson,Andrew S. Plump,Inês Barroso,Inês Barroso,Kay-Tee Khaw,Alan B. Weder,Steven C. Hunt,Yan V. Sun,Richard N. Bergman,Francis S. Collins,Lori L. Bonnycastle,Laura J. Scott,Heather M. Stringham,Leena Peltonen,Markus Perola,Erkki Vartiainen,Stefan Martin Brand,Jan A. Staessen,Thomas J. Wang,Thomas J. Wang,Paul Burton,Paul Burton,María Soler Artigas,Yanbin Dong,Harold Snieder,Harold Snieder,Xiaoling Wang,Haidong Zhu,Kurt Lohman,Megan E. Rudock,Susan R. Heckbert,Susan R. Heckbert,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Kerri L. Wiggins,Ayo P. Doumatey,Daniel Shriner,Gudrun Veldre,Margus Viigimaa,Sanjay Kinra,Dorairaj Prabhakaran,Vikal Tripathy,Carl D. Langefeld,Annika Rosengren,Dag S. Thelle,Anna Maria Corsi,Andrew B. Singleton,Terrence Forrester,Gina Hilton,Colin A. McKenzie,Tunde Salako,Naoharu Iwai,Yoshikuni Kita,Toshio Ogihara,Takayoshi Ohkubo,Takayoshi Ohkubo,Tomonori Okamura,Hirotsugu Ueshima,Satoshi Umemura,Susana Eyheramendy,Thomas Meitinger,H.-Erich Wichmann,Yoon Shin Cho,Hyung Lae Kim,Jong-Young Lee,James Scott,Joban Sehmi,Joban Sehmi,Weihua Zhang,Bo Hedblad,Peter M. Nilsson,George Davey Smith,Andrew Wong,Narisu Narisu,Alena Stančáková,Leslie J. Raffel,Jie Yao,Sekar Kathiresan,Sekar Kathiresan,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen M. Schwartz,M. Arfan Ikram,W. T. Longstreth,Thomas H. Mosley,Sudha Seshadri,Nick Shrine,Louise V. Wain,Mario A. Morken,Amy J. Swift,Jaana Laitinen,Inga Prokopenko,Inga Prokopenko,Paavo Zitting,Jackie A. Cooper,Steve E. Humphries,John Danesh,Asif Rasheed,Anuj Goel,Anders Hamsten,Hugh Watkins,Stephan J. L. Bakker,Wiek H. van Gilst,C. S. Janipalli,K. Radha Mani,Chittaranjan S. Yajnik,Albert Hofman,Francesco U.S. Mattace-Raso,Ben A. Oostra,Ayse Demirkan,Aaron Isaacs,Fernando Rivadeneira,Edward G. Lakatta,Marco Orrù,Angelo Scuteri,Mika Ala-Korpela,Mika Ala-Korpela,Antti J. Kangas,Leo-Pekka Lyytikäinen,Pasi Soininen,Pasi Soininen,Taru Tukiainen,Taru Tukiainen,Taru Tukiainen,Peter Würtz,Peter Würtz,Peter Würtz,Rick Twee-HeeOng,Rick Twee-HeeOng,Marcus Dörr,Heyo K. Kroemer,Uwe Völker,Henry Völzke,Pilar Galan,Serge Hercberg,Mark Lathrop,Diana Zelenika,Panos Deloukas,Massimo Mangino,Tim D. Spector,Guangju Zhai,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Janoš Terzić,M.V. Kranthi Kumar,Matthew Denniff,Ewa Zukowska-Szczechowska,Lynne E. Wagenknecht,F. Gerald R. Fowkes,Fadi J. Charchar,Peter Schwarz,Caroline Hayward,Xiuqing Guo,Charles N. Rotimi,Michiel L. Bots,Eva Brand,Nilesh J. Samani,Nilesh J. Samani,Ozren Polasek,Philippa J. Talmud,Fredrik Nyberg,Fredrik Nyberg,Diana Kuh,Maris Laan,Kristian Hveem,Lyle J. Palmer,Lyle J. Palmer,Yvonne T. van der Schouw,Juan P. Casas,Karen L. Mohlke,Paolo Vineis,Olli T. Raitakari,Santhi K. Ganesh,Tien Yin Wong,Tien Yin Wong,E. Shyong Tai,Richard S. Cooper,Markku Laakso,Dabeeru C. Rao,Tamara B. Harris,Richard W Morris,Anna F. Dominiczak,Mika Kivimäki,Michael Marmot,Tetsuro Miki,Danish Saleheen,Giriraj R. Chandak,Josef Coresh,Gerjan Navis,Veikko Salomaa,Bok Ghee Han,Xiaofeng Zhu,Jaspal S. Kooner,Jaspal S. Kooner,Olle Melander,Paul M. Ridker,Stefania Bandinelli,Ulf Gyllensten,Alan F. Wright,James F. Wilson,Luigi Ferrucci,Martin Farrall,Jaakko Tuomilehto,Peter P. Pramstaller,Roberto Elosua,Nicole Soranzo,Nicole Soranzo,Eric J.G. Sijbrands,David Altshuler,David Altshuler,Ruth J. F. Loos,Alan R. Shuldiner,Alan R. Shuldiner,Christian Gieger,Pierre Meneton,André G. Uitterlinden,Nicholas J. Wareham,Vilmundur Gudnason,Jerome I. Rotter,Rainer Rettig,Manuela Uda,David P. Strachan,Jacqueline C. M. Witteman,Anna-Liisa Hartikainen,Jacques S. Beckmann,Eric Boerwinkle,Ramachandran S. Vasan,Ramachandran S. Vasan,Michael Boehnke,Martin G. Larson,Martin G. Larson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Bruce M. Psaty,Bruce M. Psaty,Gonçalo R. Abecasis,Aravinda Chakravarti,Paul Elliott,Cornelia M. van Duijn,Christopher Newton-Cheh,Christopher Newton-Cheh,Daniel Levy,Mark J. Caulfield,Toby Johnson +391 more
TL;DR: A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Journal Article
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010)
Josée Dupuis,Claudia Langenberg,Inga Prokopenko,Richa Saxena,Nicole Soranzo,Anne U. Jackson,Eleanor Wheeler,Nicole L. Glazer,Nabila Bouatia-Naji,Anna L. Gloyn,C M Lindgren,Reedik Mägi,Andrew P. Morris,Joshua C. Randall,Toby Johnson,Peter J. Elliott,D Rybin,Gudmar Thorleifsson,Steinthorsdottir,Peter Henneman,H Grallert,Abbas Dehghan,J-J Hottenga,Christopher S. Franklin,Pau Navarro,KJ Song,Anuj Goel,Jrb Perry,Josephine M. Egan,Taina K. Lajunen,Niels Grarup,Thomas Sparsø,Alex S. F. Doney,B F Voight,Heather M. Stringham,Man Li,Stavroula Kanoni,Peter Shrader,Christine Cavalcanti-Proença,Meena Kumari,Lu Qi,N J Timpson,Christian Gieger,Carina Zabena,Ghislain Rocheleau,Erik Ingelsson,Ping An,Jeffery R. O'Connell,Jian'an Luan,Amanda F. Elliott,Steve McCarroll,Felicity Payne,Rosa Maria Roccasecca,François Pattou,Praveen Sethupathy,Kristin G. Ardlie,Yavuz Ariyurek,B. Balkau,Philip J. Barter,John Beilby,Yoav Ben-Shlomo,Rafn Benediktsson,Amanda J. Bennett,Sven Bergmann,Murielle Bochud,Eric Boerwinkle,Amélie Bonnefond,Lori L. Bonnycastle,Knut Borch-Johnsen,Yvonne Böttcher,Eric J. Brunner,Suzannah Bumpstead,Guillaume Charpentier,Ydi Chen,Peter S. Chines,Robert Clarke,Ljm Coin,Mark E. Cooper,Marilyn C. Cornelis,Gabriel Crawford,Laura Crisponi,Inm Day,Ejc de Geus,Jérôme Delplanque,Christian Dina,Erdos,A C Fedson,Antje Fischer-Rosinsky,Nita G. Forouhi,Caroline S. Fox,Rune R. Frants,MariaGrazia Franzosi,Pilar Galan,Mark O. Goodarzi,J. Graessler,C J Groves,Scott M. Grundy,R. Gwilliam,Ulf Gyllensten,Samy Hadjadj,Göran Hallmans,Naomi Hammond,Xijing Han,A.-L. Hartikainen,N Hassanali,Caroline Hayward,Simon C. Heath,Serge Hercberg,Christian Herder,Andrew A. Hicks,Hillman,Aroon D. Hingorani,A. Hofman,Jennie Hui,Joseph Hung,Bo Isomaa,Prv Johnson,Torben Jørgensen,A. Jula,Marika Kaakinen,J Kaprio,Y A Kesaniemi,Mika Kivimäki,Beatrice Knight,Seppo Koskinen,Peter Kovacs,Kirsten Ohm Kyvik,G. M. Lathrop,Debbie A Lawlor,O Le Bacquer,C. Lecoeur,Yun Li,Lyssenko,Robert W. Mahley,Massimo Mangino,Alisa K. Manning,María Teresa Martínez-Larrad,Jarred B. McAteer,Laura J. McCulloch,Ruth McPherson,Christine Meisinger,David Melzer,David Meyre,Braxton D. Mitchell,M. A. Morken,Sutapa Mukherjee,Silvia Naitza,Narisu Narisu,Matt J. Neville,Ben A. Oostra,Marco Orrù,Ruth E. Pakyz,Cna Palmer,Giuseppe Paolisso,Cristian Pattaro,Daniel S. Pearson,J F Peden,Nancy L. Pedersen,M. Perola,Afh Pfeiffer,Irene Pichler,Ozren Polasek,Danielle Posthuma,Simon C. Potter,A Pouta,M. A. Province,Bruce M. Psaty,Wolfgang Rathmann,N W Rayner,Kenneth Rice,S. Ripatti,Fernando Rivadeneira,Michael Roden,Olov Rolandsson,A. Sandbaek,M. S. Sandhu,Serena Sanna,Avan Aihie Sayer,Paul Scheet,Laura J. Scott,Udo Seedorf,Stephen J. Sharp,B M Shields,G Sigurosson,Ejg Sijbrands,Angela Silveira,Laila Simpson,AB Singleton,Nicholas L. Smith,Ulla Sovio,Amy J. Swift,Holly E. Syddall,Ann-Christine Syvänen,Toshiko Tanaka,Barbara Thorand,Jean Tichet,A Tönjes,Tiinamaija Tuomi,A.G. Uitterlinden,K W van Dijk,M. van Hoek,Dhiraj Varma,Sophie Visvikis-Siest,Vitart,Nicole Vogelzangs,G. Waeber,P J Wagner,Andrew Walley,G B Walters,Kim L. Ward,Hugh Watkins,Michael N. Weedon,Sarah H. Wild,Gonneke Willemsen,Jcm Witteman,Jwg Yarnell,E Zeggini,Diana Zelenika,Björn Zethelius,Guangju Zhai,Jing Hua Zhao,M. C. Zillikens,Ingrid B. Borecki,Rjf Loos,Pierre Meneton,Pke Magnusson,David M. Nathan,Gordon H. Williams,Andrew T. Hattersley,Kaisa Silander,Salomaa,George Davey Smith,Bornstein,Peter Schwarz,Jochen Spranger,F Karpe,A. R. Shuldiner,Cyrus Cooper,George Dedoussis,Manuel Serrano-Ríos,Andrew D. Morris,Lars Lind,Lyle J. Palmer,Frank B. Hu,Paul W. Franks,S Ebrahim,Michael Marmot,Whl Kao,James S. Pankow,Mike Sampson,Johanna Kuusisto,Markku Laakso,T. Hansen,Oluf Pedersen,Peter P. Pramstaller,Heinz Erich Wichmann,Thomas Illig,Igor Rudan,Alan F. Wright,Michael Stumvoll,Harry Campbell,James F. Wilson,Anders Hamsten,Richard N. Bergman,Thomas A. Buchanan,F. S. Collins,Karen L. Mohlke,J. Tuomilehto,Valle Tt,David Altshuler,Jerome I. Rotter,David S. Siscovick,Bwjh Penninx,D.I. Boomsma,Panagiotis Deloukas,Tim D. Spector,Timothy M. Frayling,L Ferrucci,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson,C M van Duijn,Y S Aulchenko,Anyuan Cao,Angelo Scuteri,David Schlessinger,Manuela Uda,Aimo Ruokonen,Jarvelin,Dawn M. Waterworth,Peter Vollenweider,Leena Peltonen,Mooser,Gonçalo R. Abecasis,Nicholas J. Wareham,Robert Sladek,Philippe Froguel,Richard M. Watanabe,James B. Meigs,Leif Groop,Michael Boehnke,Mark I. McCarthy,Jose C. Florez,Ines Barroso Magic Investigators +303 more
Journal ArticleDOI
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Cristen J. Willer,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Ruth J. F. Loos,Shengxu Li,Cecilia M. Lindgren,Iris M. Heid,Sonja I. Berndt,Amanda F. Elliott,Amanda F. Elliott,Anne U. Jackson,Claudia Lamina,Guillaume Lettre,Guillaume Lettre,Noha Lim,Helen N. Lyon,Helen N. Lyon,Steven A. McCarroll,Steven A. McCarroll,Konstantinos A. Papadakis,Lu Qi,Joshua C. Randall,Rosa Maria Roccasecca,Serena Sanna,Paul Scheet,Michael N. Weedon,Eleanor Wheeler,Jing Hua Zhao,Leonie C. Jacobs,Inga Prokopenko,Nicole Soranzo,Nicole Soranzo,Toshiko Tanaka,Nicholas J. Timpson,Peter Almgren,Amanda J. Bennett,Richard N. Bergman,Sheila Bingham,Lori L. Bonnycastle,Morris Brown,Noël P. Burtt,Peter S. Chines,Lachlan J. M. Coin,Francis S. Collins,John M. C. Connell,Cyrus Cooper,George Davey Smith,Elaine M. Dennison,Parimal Deodhar,Paul Elliott,Michael R. Erdos,Karol Estrada,David M. Evans,Lauren Gianniny,Christian Gieger,Christopher J. Gillson,Candace Guiducci,Rachel Hackett,David Hadley,Alistair S. Hall,Aki S. Havulinna,Johannes Hebebrand,Albert Hofman,Bo Isomaa,Kevin B. Jacobs,Toby Johnson,Toby Johnson,Pekka Jousilahti,Zorica Jovanovic,Zorica Jovanovic,Kay-Tee Khaw,Peter Kraft,Mikko Kuokkanen,Mikko Kuokkanen,Johanna Kuusisto,Jaana Laitinen,Edward G. Lakatta,Jian'an Luan,Robert Luben,Massimo Mangino,Wendy L. McArdle,Thomas Meitinger,Antonella Mulas,Patricia B. Munroe,Narisu Narisu,Andy R Ness,Kate Northstone,Stephen O'Rahilly,Stephen O'Rahilly,Carolin Purmann,Carolin Purmann,Matthew G. Rees,Martin Ridderstråle,Susan M. Ring,Fernando Rivadeneira,Aimo Ruokonen,Manjinder S. Sandhu,Manjinder S. Sandhu,Jouko Saramies,Laura J. Scott,Angelo Scuteri,Kaisa Silander,Matthew A. Sims,Kijoung Song,Jonathan Stephens,Suzanne Stevens,Heather M. Stringham,Y. C. Loraine Tung,Y. C. Loraine Tung,Timo T. Valle,Cornelia M. van Duijn,Karani Santhanakrishnan Vimaleswaran,Karani Santhanakrishnan Vimaleswaran,Peter Vollenweider,Gérard Waeber,Chris Wallace,Richard M. Watanabe,Dawn M. Waterworth,Nicholas A. Watkins,Jacqueline C. M. Witteman,Eleftheria Zeggini,Guangju Zhai,M. Carola Zillikens,David Altshuler,David Altshuler,Mark J. Caulfield,Stephen J. Chanock,I. Sadaf Farooqi,I. Sadaf Farooqi,Luigi Ferrucci,Jack M. Guralnik,Andrew T. Hattersley,Frank B. Hu,Marjo-Riitta Järvelin,Markku Laakso,Vincent Mooser,Ken K. Ong,Willem H. Ouwehand,Willem H. Ouwehand,Veikko Salomaa,Nilesh J. Samani,Tim D. Spector,Tiinamaija Tuomi,Jaakko Tuomilehto,Manuela Uda,André G. Uitterlinden,Nicholas J. Wareham,Panagiotis Deloukas,Timothy M. Frayling,Leif Groop,Leif Groop,Richard B. Hayes,David J. Hunter,David J. Hunter,Karen L. Mohlke,Leena Peltonen,Leena Peltonen,Leena Peltonen,David Schlessinger,David P. Strachan,H-Erich Wichmann,Mark I. McCarthy,Michael Boehnke,Inês Barroso,Gonçalo R. Abecasis,Joel N. Hirschhorn,Joel N. Hirschhorn +166 more
TL;DR: Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.