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Amanda M. Lauer
Researcher at Johns Hopkins University School of Medicine
Publications - 61
Citations - 1190
Amanda M. Lauer is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Hearing loss & Medicine. The author has an hindex of 18, co-authored 50 publications receiving 771 citations. Previous affiliations of Amanda M. Lauer include University of Maryland, College Park & Johns Hopkins University.
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Journal ArticleDOI
Efferent synapses return to inner hair cells in the aging cochlea.
TL;DR: Investigation of changes to efferent innervation in the vicinity of inner hair cells in young and old C57BL/6 mice using transmission electron microscopy revealed increased efferentinnervation of IHCs in older animals, associated with increased outer hair cell loss, and elevated auditory brainstem response thresholds.
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TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells.
Christopher L. Cunningham,Xufeng Qiu,Zizhen Wu,Bo Zhao,Guihong Peng,Ye-Hyun Kim,Amanda M. Lauer,Ulrich Müller +7 more
TL;DR: TMIE is a subunit of the cochlear mechanotransduction channel and that channel function is regulated by a phospholipid-sensing domain in TMIE with similarity to those in other mechanically gated ion channels.
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Efferent inhibition of the cochlea
Paul A. Fuchs,Amanda M. Lauer +1 more
TL;DR: Through its actions on cochlear hair cells, afferent neurons, and higher centers, the olivocochlear system protects against age-related and noise-induced hearing loss, improves signal coding in noise under certain conditions, modulates selective attention to sensory stimuli, and influences sound localization.
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GluA4 is indispensable for driving fast neurotransmission across a high-fidelity central synapse
Yi Mei Yang,Jamila Aitoubah,Amanda M. Lauer,Mutsuo Nuriya,Kogo Takamiya,Zhengping Jia,Bradford J. May,Richard L. Huganir,Lu-Yang Wang +8 more
TL;DR: It is found that elimination of GluA4, a protein particularly abundant in auditory cells, significantly impairs their ability to faithfully transmit electric signals, leading to profound deficits in auditory responses to sound stimuli in mice.
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Analysis of environmental sound levels in modern rodent housing rooms
TL;DR: Noise in animal housing facilities is an environmental variable that can affect hearing, behavior and physiology in mice and attempts to reduce noise should concentrate on controlling sounds produced by in-room activities and experimenter traffic to reduce the variability of research outcomes and improve animal welfare.