Kogo Takamiya

TL;DR: It is demonstrated that phosphorylation of GluR1 is critical for LTD and LTP expression and the retention of memories.

TL;DR: Examination of the role of NE in contextual memory formation and in the synaptic delivery of GluR1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA)-type glutamate receptors during long-term potentiation (LTP), a candidate synaptic mechanism for learning, indicates that NE-driven phosphorylation of GLUR1 facilitates the synaptic deliveries of Glamorganically-containing AMPARs.

TL;DR: It is shown that in visual cortex the rules of this spike-timing-dependent plasticity are not rigid, but shaped by neuromodulator receptors coupled to adenylyl cyclase (AC) and phospholipase C (PLC) signaling cascades.

TL;DR: The generation of mice with a disrupted beta 1,4-N-acetylgalactosaminyltransferase (GM2/GD2 synthase) gene suggest that complex gangliosides are required in neuronal functions but not in the morphogenesis and organogenesis of the brain.

TL;DR: A synapse-specific role for PSD-95 in controlling synaptic function that is independent of spine morphology is suggested, which is related to the greater magnitude of potentiation after long-term potentiation induction observed in these mice.