Amanda Oldani

TL;DR: A gut-vascular barrier (GVB) in mice and humans that controls the translocation of antigens into the blood stream and prohibits entry of the microbiota is identified and may provide new insights into the regulation of the gut-liver axis.

TL;DR: It is proposed that Rpd3, Hda1 and Gcn5 control chromosome stability by coordinating the ATR checkpoint and double-strand-break processing with autophagy, and it is found that HDAC inhibition triggers Sae2 degradation by promoting Autophagy that affects the DNA damage sensitivity of hda 1 and rpd3 mutants.

TL;DR: It is shown that RAB5A, a key endocytic protein, is sufficient to induce large-scale, coordinated motility over tens of cells and ballistic motion in otherwise kinetically-arrested monolayers, which enable collectives to migrate under physical constraints and may be exploited by tumors for interstitial dissemination.

TL;DR: It is proposed that the assembly of DSB-induced transcriptional promoters drives RNA synthesis, which stimulates phase separation of DDR factors in the shape of foci, and that dilncRNAs drive molecular crowding of DDR proteins into foci that exhibit liquid–liquid phase- separation condensate properties.

TL;DR: It is shown that, upon exposure to CCL19 or CXCL12 gradients, malignant B and T lymphocytes assemble into clusters that migrate directionally and display a wider chemotactic sensitivity than individual cells.